ArticleAngewandte Chemie (International ed. in English)2017
Enantioselective Synthesis of Acyclic α-Quaternary Carboxylic Acid Derivatives through Iridium-Catalyzed Allylic Alkylation.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Mo-Catalyzed Asymmetric Allylic Alkylation Enabling the Construction of Highly Enantioenriched 1,4-Dicarbonyl Scaffolds.Journal of the American Chemical Society · 2025Article
- Formation of Vicinal Secondary and All-Carbon Quaternary Stereocenters in Enantioenriched Diazenes via Branched-Selective Pd-Catalyzed Allylic Alkylation.Tetrahedron letters · 2025Article
- Construction of Vicinal Quaternary Centers via Ru-Catalyzed Enantiospecific Allylic Substitution with Lithium Ester Enolates.Journal of the American Chemical Society · 2024Article
- Scope and Mechanistic Probe into Asymmetric Synthesis of α-Trisubstituted-α-Tertiary Amines by Rhodium Catalysis.Journal of the American Chemical Society · 2023Article
- Hydroxy-directed iridium-catalyzed enantioselective formal β-C(spChemical science · 2022Article
- Ir-Catalyzed Asymmetric Allylic Alkylation of Dialkyl Malonates Enabling the Construction of Enantioenriched All-Carbon Quaternary Centers.Journal of the American Chemical Society · 2022Article
- CuH-Catalyzed Regio- and Enantioselective Hydrocarboxylation of Allenes: Toward Carboxylic Acids with Acyclic Quaternary Centers.Journal of the American Chemical Society · 2021Article
- Iridium-catalyzed enantioselective olefinic C(spChemical science · 2021Article
- Mechanistic insights into rhodium-catalyzed enantioselective allylic alkylation for quaternary stereogenic centers.Chemical science · 2020Article
- Catalytic enantioselective allene-anhydride approach to β,γ-unsaturated enones bearing an α-all-carbon-quarternary center.Chemical science · 2020Article
- Article
- Palladium-catalyzed enantioselective decarboxylative allylic alkylation of fully substitutedChemical science · 2019Article
- Cyclometalated Iridium-PhanePhos Complexes Are Active Catalysts in Enantioselective Allene-Fluoral Reductive Coupling and Related Alcohol-Mediated Carbonyl Additions That Form Acyclic Quaternary Carbon Stereocenters.Journal of the American Chemical Society · 2019Article
- Intermolecular Stereoselective Iridium-Catalyzed Allylic Alkylation: An Evolutionary Account.Synlett : accounts and rapid communications in synthetic organic chemistry · 2018Article
- Catalytic Enantioselective Synthesis of Acyclic Quaternary Centers: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Acyclic Enol Carbonates.Journal of the American Chemical Society · 2018Article
- Iridium-catalyzed enantioselective direct vinylogous allylic alkylation of coumarins.Chemical science · 2018Article
- Enantioselective Synthesis of Vicinal All-Carbon Quaternary Centers via Iridium-Catalyzed Allylic Alkylation.Angewandte Chemie (International ed. in English) · 2018Article
- Article
- Nickel-catalyzed enantioselective allylic alkylation of lactones and lactams with unactivated allylic alcohols.Chemical science · 2018Article
- Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis.Journal of the American Chemical Society · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The first highly enantioselective iridium-catalyzed allylic alkylation that provides access to products bearing an allylic all-carbon quaternary stereogenic center has been developed. The reaction utilizes a masked acyl cyanide (MAC) reagent, which enables the one-pot preparation of α-quaternary carboxylic acids, esters, and amides with a high degree of enantioselectivity. The utility of these products is further explored through a series of diverse product transformations.
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