ArticleNature communications2017
Silk micrococoons for protein stabilisation and molecular encapsulation.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 133 citations in OpenAlex.
- The stage-wise macromolecular assembly and structure evolution of silk along the silk gland.Nature communications · 2026Article
- Cryo-ET comparison of the hierarchical ultrastructure of silkworm, spider, and artificial silk fibers.Nature communications · 2026Article
- Silk protein plastics for sustained and controlled drug release.International journal of pharmaceutics · 2026Article
- Feeling the vibes: Vibrational spectroscopic imaging of biomolecular assemblies in their natural environment.Applied physics reviews · 2025Article
- Amyloid-Like Self-Assembling of Black Soldier Fly Proteins and Development of Bioplastics.ACS sustainable chemistry & engineering · 2025Article
- Article
- Biosynthesis of a dual growth factors (GFs) functionalized silk sericin hydrogel to promote chronic wound healing in diabetic mice.Bioactive materials · 2025Article
- Biomimetic Silk Nanoparticle Manufacture: Calcium Ion-Mediated Assembly.ACS biomaterials science & engineering · 2025Article
- Fine Structural Analysis of Degummed Fibroin Fibers Reveals Its Superior Mechanical Capabilities.ChemSusChem · 2025Article
- From Basic Principles of Protein-Polysaccharide Association to the Rational Design of Thermally Sensitive Materials.ACS applied materials & interfaces · 2024Article
- Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases.Molecular neurodegeneration · 2024Review
- A novel computationally engineered collagenase reduces the force required for tooth extraction in an ex-situ porcine jaw model.Journal of biological engineering · 2023Article
- Microcompartmentalization Controls Silk Feedstock Rheology.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Article
- Kinetic Analysis Reveals the Role of Secondary Nucleation in Regenerated Silk Fibroin Self-Assembly.Biomacromolecules · 2023Article
- Micro and nano-scale compartments guide the structural transition of silk protein monomers into silk fibers.Nature communications · 2022Article
- Permeability-Engineered Compartmentalization Enables In Vitro Reconstitution of Sustained Synthetic Biology Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Challenges in delivering therapeutic peptides and proteins: A silk-based solution.Journal of controlled release : official journal of the Controlled Release Society · 2022Review
- Volumetric Scalability of Microfluidic and Semi-Batch Silk Nanoprecipitation Methods.Molecules (Basel, Switzerland) · 2022Article
- Protein-Based Encapsulation Strategies: Toward Micro- and Nanoscale Carriers with Increased Functionality.Small science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naturally spun silks generate fibres with unique properties, including strength, elasticity and biocompatibility. Here we describe a microfluidics-based strategy to spin liquid native silk, obtained directly from the silk gland of Bombyx mori silkworms, into micron-scale capsules with controllable geometry and variable levels of intermolecular β-sheet content in their protein shells. We demonstrate that such micrococoons can store internally the otherwise highly unstable liquid native silk for several months and without apparent effect on its functionality. We further demonstrate that these native silk micrococoons enable the effective encapsulation, storage and release of other aggregation-prone proteins, such as functional antibodies. These results show that native silk micrococoons are capable of preserving the full activity of sensitive cargo proteins that can aggregate and lose function under conditions of bulk storage, and thus represent an attractive class of materials for the storage and release of active biomolecules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.