SynthesisSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Hepatitis C virus infection and risk of osteoporosis: A meta-analysis.
Synthesis in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- An explainable machine learning model for predicting osteoporotic fragility fractures: a retrospective study in South China.Frontiers in medicine · 2026Article
- Abnormal Trabecular and Cortical Bone Microarchitecture in Chronic Hepatitis C Infection and Associations With Select Inflammatory Cytokines.Open forum infectious diseases · 2025Article
- A case-control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women.BMC medicine · 2025Article
- Impact of HCV cure on systemic inflammation and bone density, quality, and turnover.Frontiers in immunology · 2025Article
- Association between Chronic Hepatitis B/C and Incidence of Osteoporosis and Bone Fractures: Results from a Retrospective Cohort Study.Journal of clinical medicine · 2024Article
- Emerging role of liver-bone axis in osteoporosis.Journal of orthopaedic translation · 2024Review
- Association of chronic liver disease with bone diseases and muscle weakness.Journal of bone and mineral metabolism · 2024Review
- Bone Disease in HIV: Need for Early Diagnosis and Prevention.Life (Basel, Switzerland) · 2024Review
- Association between hepatitis A seropositivity and bone mineral density in adolescents and adults: a cross-sectional study using NHANES data.Sao Paulo medical journal = Revista paulista de medicina · 2024Article
- Risk factors for fractures following liver transplantation: a population-based cohort study.Annals of medicine · 2023Article
- Osteoporosis and associated risk factors in patients with severe hemophilia A: a case-control study from China.BMC musculoskeletal disorders · 2023Article
- Hepatitis C and Thalassemia: A Story with (Almost) a Happy Ending.Pathogens (Basel, Switzerland) · 2023Review
- Massive Periprosthetic Osteolysis Spreads to the Soft Tissue and Pelvic Region after Primary Total Hip Replacement: A Case Report.Journal of orthopaedic case reports · 2023Article
- Seropositive for hepatitis B and C viruses is associated with the risk of decreased bone mineral density in adults: An analysis of studies from the NHANES database.Frontiers in medicine · 2023Article
- Prevalence and predictors of post-liver transplantation metabolic bone diseases.Clinical and experimental hepatology · 2021Article
- Review
- Article
- Investigation of the influential factors for hepatic osteodystrophy in chronic liver disease: A case-control survey among the patients attending a tertiary care hospital in a rural region of Northern India.Tzu chi medical journalArticle
- Bone mineral density loss in patients with cirrhosis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsHepatitis C virus (HCV) infection is one of the most common infections worldwide. Several epidemiologic studies have suggested that patients with HCV infection might be at an increased risk of osteoporosis. However, the data on this relationship remains inconclusive. This meta-analysis was conducted with the aim to summarize all available evidence. MATERIALS AND
methodsA literature search was performed using MEDLINE and EMBASE databases from inception to June 2016. Studies that reported relative risks, odd ratios (OR), or hazard ratios comparing the risk of osteoporosis among HCV-infected patients versus those without HCV infection were included. Pooled OR and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.
resultsFour studies met our eligibility criteria and were included in the analysis. We found a higher risk of osteoporosis among patients with chronic HCV with OR of 1.65 (95% CI: 0.98-2.77). Sensitivity analysis including only studies with higher quality yielded a higher OR, and the result was statistically significant (OR: 2.47; 95% CI: 1.03-5.93).
conclusionsOur study demonstrated a higher risk of osteoporosis among HCV-infected patients. Further studies are required to clarify how this risk should be addressed in clinical practice.
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