ArticleMolecular imaging and biology2018
How to Provide Gadolinium-Free PET/MR Cancer Staging of Children and Young Adults in Less than 1 h: the Stanford Approach.
Article in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Clinical PET/MR.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Comparison of diffusion-weighted MRI and [European radiology · 2024Review
- Algorithm for Reducing Overall Biological Detriment Caused by PET/CT: an Age-Based Study.Nuclear medicine and molecular imaging · 2023Article
- Ferumoxytol-Enhanced MRI in Children and Young Adults: State of the Art.AJR. American journal of roentgenology · 2023Article
- One-stop local and whole-body staging of children with cancer.Pediatric radiology · 2022Review
- How to stop using gadolinium chelates for magnetic resonance imaging: clinical-translational experiences with ferumoxytol.Pediatric radiology · 2022Review
- Validation of Deep Learning-based Augmentation for ReducedRadiology. Artificial intelligence · 2021Article
- Artificial intelligence enables whole-body positron emission tomography scans with minimal radiation exposure.European journal of nuclear medicine and molecular imaging · 2021Article
- An international expert opinion statement on the utility of PET/MR for imaging of skeletal metastases.European journal of nuclear medicine and molecular imaging · 2021Article
- Therapy Response Assessment of Pediatric Tumors with Whole-Body Diffusion-weighted MRI and FDG PET/MRI.Radiology · 2020Article
- Whole-Body [Molecular imaging and biology · 2020Article
- Brain iron deposition after Ferumoxytol-enhanced MRI: A study of Porcine Brains.Nanotheranostics · 2020Article
- An alternative approach to contrast-enhanced imaging: diffusion-weighted imaging and TEuropean radiology · 2019Article
- Tracking Stem Cell Implants in Cartilage Defects of Minipigs by Using Ferumoxytol-enhanced MRI.Radiology · 2019Article
- Whole-body PET/MRI of Pediatric Patients: The Details That Matter.Journal of visualized experiments : JoVE · 2017Article
- Synergy of PET and MR imaging in the local and regional staging of bladder cancer.Therapeutic advances in urologyReview
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h. PROCEDURES: In this prospective clinical trial, 20 children and young adults (11-30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[
resultsTailored workflows significantly reduced scan times from 36 to 24 min for head to mid thigh scans (p < 0.001). These streamlined PET/MR scans were obtained with significantly reduced radiation exposure (mean 3.4 mSv) compared to PET/CT with diagnostic CT (mean 13.1 mSv; p = 0.003). Using the iron supplement ferumoxytol "off label" as an MR contrast agent avoided gadolinium chelate administration. The ferumoxytol-enhanced PET/MR scans provided equal or superior tumor staging results compared to clinical standard tests in 17 out of 20 patients. Compared to PET/CT, PET/MR had comparable detection rates for pulmonary nodules with diameters of equal or greater than 5 mm (94 vs. 100 %), yet detected significantly fewer nodules with diameters of less than 5 mm (20 vs 100 %) (p = 0.03). [
conclusionOur streamlined ferumoxytol-enhanced PET/MR protocol provided cancer staging of children and young adults in less than 1 h with equivalent or superior clinical information compared to clinical standard staging tests. The detection of small pulmonary nodules with PET/MR needs to be improved.
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