ArticleDiabetologia2017
Age at natural menopause and risk of type 2 diabetes: a prospective cohort study.
Article in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Variations in reproductive events across life: a pooled analysis of data from 505 147 women across 10 countries.Human reproduction (Oxford, England) · 2019Pooled it
- Lifestyle factors, cardiovascular disease and all-cause mortality in middle-aged and elderly women: a systematic review and meta-analysis.European journal of epidemiology · 2018Pooled it
- Reproductive lifespan in relation to diabetes mellitus and metabolic syndrome in a nationally representative population.BMJ open diabetes research & care · 2026Article
- Age at Menopause and Trajectories of Multimorbidity Progression to Mortality: A Multi-State Analysis of UK Biobank Data.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- A qualitative study of midlife women with type 2 diabetes in the UK: Exploring the impact of diabetes on their well-being.PloS one · 2026Article
- Association of age at menopause with cardiovascular disease and mortality:insights from NHANES and a clinical cohort.Frontiers in cardiovascular medicine · 2026Article
- Position Statement on Cardiometabolic Health Across the Woman's Life Course - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Studying ovarian aging and its health impacts: modern tools and approaches.Genes & development · 2025Review
- Association of menarche, menopause, and reproductive history with cognitive performance in older US women: a cross-sectional study from NHANES 2011-2014.BMC public health · 2025Article
- Classification and identification of risk factors for type 2 diabetes.World journal of diabetes · 2025Review
- Age at Menopause and Development of Type 2 Diabetes in Korea.JAMA network open · 2025Article
- Deciphering the role of classical oestrogen receptor in insulin resistance and type 2 diabetes mellitus: From molecular mechanism to clinical evidence.BioImpacts : BI · 2025Review
- Position Statement on Cardiometabolic Health Across the Woman's Life Course - 2025.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Development and External Validation of a Home-based Risk Prediction Model of Natural Onset of Menopause-Teuta.The Journal of clinical endocrinology and metabolism · 2024Article
- Association of age at menopause with type 2 diabetes mellitus in postmenopausal women: a systematic review and meta-analysis.Przeglad menopauzalny = Menopause review · 2024Review
- The association between age of menopause and type 2 diabetes: a systematic review and meta-analysis.Nutrition & metabolism · 2024Article
- HNF1A gene mutations and premature ovarian failure (POF): evidence from a clinical paradigm combining MODY 3 and POF.Hormones (Athens, Greece) · 2024Review
- Association between breastfeeding duration and diabetes mellitus in menopausal women: a machine-learning analysis using population-based retrospective study.International breastfeeding journal · 2024Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisIn this study, we aimed to examine the association between age at natural menopause and risk of type 2 diabetes, and to assess whether this association is independent of potential mediators.
methodsWe included 3639 postmenopausal women from the prospective, population-based Rotterdam Study. Age at natural menopause was self-reported retrospectively and was treated as a continuous variable and in categories (premature, <40 years; early, 40-44 years; normal, 45-55 years; and late menopause, >55 years [reference]). Type 2 diabetes events were diagnosed on the basis of medical records and glucose measurements from Rotterdam Study visits. HRs and 95% CIs were calculated using Cox proportional hazards models, adjusted for confounding factors; in another model, they were additionally adjusted for potential mediators, including obesity, C-reactive protein, glucose and insulin, as well as for levels of total oestradiol and androgens.
resultsDuring a median follow-up of 9.2 years, we identified 348 individuals with incident type 2 diabetes. After adjustment for confounders, HRs for type 2 diabetes were 3.7 (95% CI 1.8, 7.5), 2.4 (95% CI 1.3, 4.3) and 1.60 (95% CI 1.0, 2.8) for women with premature, early and normal menopause, respectively, relative to those with late menopause (p CONCLUSIONS/
interpretationEarly onset of natural menopause is an independent marker for type 2 diabetes in postmenopausal women.
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