ArticleNPJ breast cancer2016
Relationships between pathology and crystal structure in breast calcifications: an
Article in NPJ breast cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- From diagnostic marker-to-therapeutic modality: emerging paradigms in tumor biomineralization.Cancer biology & medicine · 2026Review
- Prostate microcalcification crystallography as a marker of pathology.Scientific reports · 2025Article
- Characterization of dolomite and calcite microcalcifications in human breast tissue.RSC advances · 2024Article
- Article
- Whitlockite has a characteristic distribution in mammary microcalcifications and it is not associated with breast cancer.Cancer communications (London, England) · 2023Article
- New insights into breast microcalcification for poor prognosis: NACT cohort and bone metastasis evaluation cohort.Journal of cancer research and clinical oncology · 2023Article
- Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer.Analytical methods : advancing methods and applications · 2023Article
- Biomineralogical signatures of breast microcalcifications.Science advances · 2023Article
- Fast X-ray diffraction (XRD) tomography for enhanced identification of materials.Scientific reports · 2022Article
- Breast calcification micromorphology classification.The British journal of radiology · 2022Article
- A multi-modal exploration of heterogeneous physico-chemical properties of DCIS breast microcalcifications.The Analyst · 2022Article
- A time-course Raman spectroscopic analysis of spontaneous in vitro microcalcifications in a breast cancer cell line.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Multiple Pathways for Pathological Calcification in the Human Body.Advanced healthcare materials · 2021Review
- Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Quantitative chemical imaging of breast calcifications in association with neoplastic processes.Theranostics · 2020Article
- Calcification Microstructure Reflects Breast Tissue Microenvironment.Journal of mammary gland biology and neoplasia · 2019Article
- Hydroxyapatite mineral enhances malignant potential in a tissue-engineered model of ductal carcinoma in situ (DCIS).Biomaterials · 2019Article
- Pathological Mineralization: The Potential of Mineralomics.Materials (Basel, Switzerland) · 2019Review
- Subsurface Chemically Specific Measurement of pH Levels in Biological Tissues Using Combined Surface-Enhanced and Deep Raman.Analytical chemistry · 2019Article
- X-ray scanning microscopies of microcalcifications in abdominal aortic and popliteal artery aneurysms.IUCrJ · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcifications are not only one of the most important early diagnostic markers of breast cancer, but are also increasingly believed to aggravate the proliferation of cancer cells and invasion of surrounding tissue. Moreover, this influence appears to vary with calcification composition. Despite this, remarkably little is known about the composition and crystal structure of the most common type of breast calcifications, and how this differs between benign and malignant lesions. We sought to determine how the phase composition and crystallographic parameters within calcifications varies with pathology, using synchrotron X-ray diffraction. This is the first time crystallite size and lattice parameters have been measured in breast calcifications, and we found that these both parallel closely the changes in these parameters with age observed in fetal bone. We also discovered that these calcifications contain a small proportion of magnesium whitlockite, and that this proportion increases from benign to
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.