Evidence map›Paper›PMID 28721274›Full record

ArticleNPJ aging and mechanisms of disease2016

Increased oxidative phosphorylation in response to acute and chronic DNA damage.

Lear E Brace, Sarah C Vose, Kristopher Stanya, Rose M Gathungu, Vasant R Marur, Alban Longchamp, Humberto Treviño-Villarreal, Pedro Mejia, Dorathy Vargas, Karen Inouye and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ aging and mechanisms of disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 116 citations in OpenAlex.

  1. BPTF is essential for vaccine-induced germinal center B cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Lear E BraceDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-6961-9758
Sarah C VoseDivision of Environmental Health, Vermont Department of Health, Burlington, VT, USA.
Kristopher StanyaDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Rose M GathunguDepartment of Neurosurgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Vasant R MarurDepartment of Neurosurgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Alban LongchampDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Humberto Treviño-VillarrealDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Pedro MejiaDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Dorathy VargasDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Karen InouyeDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Roderick T BronsonRodent Histopathology Core, Department of Pathology, Harvard Medical School, Boston, MA, USA.
Chih-Hao LeeDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Edward NeilanGenetics and Metabolism Division, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Bruce S KristalDepartment of Neurosurgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
James R MitchellDepartment of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USBoston Children's Hospital · USVermont Department of Health · US

Funding

Mechanisms of dietary control of the transsulfuration pathway and increased endogenous hydrogen sulfide productionR01DK090629 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, SARAH JAYNE · 2011 to 2019
$3.0M
NIDDK NIH HHS R01 DK090629
6 · The paper itself

Abstract

Accumulation of DNA damage is intricately linked to aging, aging-related diseases and progeroid syndromes such as Cockayne syndrome (CS). Free radicals from endogenous oxidative energy metabolism can damage DNA, however the potential of acute or chronic DNA damage to modulate cellular and/or organismal energy metabolism remains largely unexplored. We modeled chronic endogenous genotoxic stress using a DNA repair-deficient

Identifiers

PMID28721274
PMCPMC5514997
OpenAlexW2531423675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.