ArticleNPJ aging and mechanisms of disease2016
Cytochrome
Open access · goldAbstract read
In one paragraph
Article in NPJ aging and mechanisms of disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Effects of tetrahydroindenoindole supplementation on metabolism: A systematic review with meta-analysis of rodent-based studies.GeroScience · 2026Pooled it
- The CYB5R3-mARC1 Redox Axis in Metabolic Dysfunction-associated Steatotic Liver Disease: Mechanistic Basis and Therapeutic Prospects across the Steatosis-Cirrhosis-Hepatocellular Carcinoma Spectrum.Journal of clinical and translational hepatology · 2026Review
- Divergence of the CYB5R3-mARC1 Redox Axis Across the Human MASLD-to-Hepatocellular-Carcinoma Continuum: An Exploratory Analysis of Liver-Biopsy and Tumor Cohorts.International journal of molecular sciences · 2026Article
- Deciphering cytochrome P450 reductase role in MASLD: molecular mechanisms and pathophysiological implications.Nature reviews. Gastroenterology & hepatology · 2026Review
- Cytochrome bBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026Article
- Transcriptome and DNA Methylation Analyses Provide Insight into Environmental Adaptation in Northern and Southern Populations ofAnimals : an open access journal from MDPI · 2026Article
- Article
- The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan.Nature aging · 2025Article
- Cytochrome b5 reductase orchestrates IL-1β production in macrophages through FAD.Cell death & disease · 2025Article
- Sex-dependent adaptations in heart mitochondria from transgenic mice overexpressing cytochrome bMitochondrion · 2025Article
- Mitoregulin, a tiny protein at the crossroads of mitochondrial functioning, stress, and disease.Frontiers in cell and developmental biology · 2025Review
- CYB5R3 T117S tempers fetal hemoglobin induction by hydroxyurea in patients with sickle cell disease.Blood advances · 2024Article
- Cytochrome bAging cell · 2024Article
- Fibre-specific mitochondrial protein abundance is linked to resting and post-training mitochondrial content in the muscle of men.Nature communications · 2024Article
- Altered Levels of Gene Expression of Drug Metabolism Enzymes in Rat Brain Following Kainic Acid Treatment.Turkish journal of pharmaceutical sciences · 2024Article
- Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.Cell death & disease · 2024Article
- CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways.Experimental & molecular medicine · 2024Article
- Vitamin E/Coenzyme Q-Dependent "Free Radical Reductases": Redox Regulators in Ferroptosis.Antioxidants & redox signaling · 2024Review
- Cyb5r3 activation rescues secondary failure to sulfonylurea but not β-cell dedifferentiation.PloS one · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 8 institutions in 2 countries.
Alejandro Martin-MontalvoTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Yaning SunTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Alberto Diaz-RuizTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Ahmed AliTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Vincent GutierrezTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Hector H PalaciosTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Jessica CurtisTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Emilio SiendonesCentro Andaluz de Biología del Desarrollo, and CIBERER, Instituto de Salud Carlos III, Universidad Pablo de Olavide-CSIC, Sevilla, Spain.
Julia ArizaDepartamento de Biología Celular, Fisiología e Inmunología, Facultad de Ciencias, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, Córdoba, Spain.
Gelareh A AbulwerdiTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Xiaoping SunTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Annie X WangTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Kevin J PearsonTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Kenneth W FishbeinMagnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Richard G SpencerMagnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Miao WangDiabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL, USA.
Xianlin HanDiabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute, Orlando, FL, USA.
Morten Scheibye-KnudsenLaboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Joe A BaurDepartment of Physiology, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA, USA.
Howard G ShertzerDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Placido NavasCentro Andaluz de Biología del Desarrollo, and CIBERER, Instituto de Salud Carlos III, Universidad Pablo de Olavide-CSIC, Sevilla, Spain.
Jose Manuel VillalbaDepartamento de Biología Celular, Fisiología e Inmunología, Facultad de Ciencias, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, Córdoba, Spain.
Sige ZouTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Michel BernierTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Rafael de CaboTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
National Institutes of Health · USNational Institute on Aging · USSanford Burnham Prebys Medical Discovery Institute · USUniversity of Córdoba · ESCentro Andaluz de Biología del Desarrollo · ESInstituto de Salud Carlos III · ESUniversity of Cincinnati Medical Center · USUniversity of Pennsylvania · US
Funding
Magnetic Resonance Imaging and Spectroscopy of Rodent Models of DiseaseZIAAG000927 · NIA · NATIONAL INSTITUTE ON AGING · PI SPENCER, RICHARD · 2009 to 2025
$5.3MNRF2 interactions with SIRT1 and its role on caloric restrictionZIAAG000361 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2024
$5.3MAging and CR effects on the Plasma Membrane Redox SystemZIAAG000362 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$5.0MShotgun Lipidomics and Alterations in Sphingolipidomes in Alzheimer's DiseasesR01AG031675 · NIA · WASHINGTON UNIVERSITY · PI HAN, XIANLIN · 2007 to 2011
$2.8MIdentification of altered lipids predictive of anesthetic-induced brain injuryR01GM105724 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HAN, XIANLIN · 2013 to 2016
$1.8MNIA NIH HHS R01 AG031675NIGMS NIH HHS R01 GM105724
Abstract
Cytochrome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.