ArticleNPJ aging and mechanisms of disease2016
Yeast longevity promoted by reversing aging-associated decline in heavy isotope content.
Article in NPJ aging and mechanisms of disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Heavy Water Remodels the DNA Energy Landscape to Stabilize Folded States and Slow Transitions.ACS physical chemistry Au · 2026Article
- Kinetic Isotope Effect in the Unfolding of a Protein Secondary Structure: Calculations for Beta-Sheet Polyglycine Dimers as a Model.Biomolecules · 2025Article
- Divergent Molecular Responses to Heavy Water inPlants (Basel, Switzerland) · 2024Article
- Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functions.Life science alliance · 2024Article
- The biological impact of deuterium and therapeutic potential of deuterium-depleted water.Frontiers in pharmacology · 2024Review
- Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging.Cell metabolism · 2023Article
- Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Possible Mechanisms of Biological Effects Observed in Living Systems duringMolecules (Basel, Switzerland) · 2019Review
- Deuterium-Depleted Water Influence on the IsotopeNutrients · 2019Review
- Metformin Affects Heme Function as a Possible Mechanism of Action.G3 (Bethesda, Md.) · 2019Article
- Genetic cartography of longevity in humans and mice: Current landscape and horizons.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- KineticScientific reports · 2017Article
- Shifts in rotifer life history in response to stable isotope enrichment: testing theories of isotope effects on organismal growth.Royal Society open science · 2017Article
- Can heavy isotopes increase lifespan? Studies of relative abundance in various organisms reveal chemical perspectives on aging.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysregulation of metabolism develops with organismal aging. Both genetic and environmental manipulations promote longevity by effectively diverting various metabolic processes against aging. How these processes converge on the metabolome is not clear. Here we report that the heavy isotopic forms of common elements, a universal feature of metabolites, decline in yeast cells undergoing chronological aging. Supplementation of deuterium, a heavy hydrogen isotope, through heavy water (D
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.