ArticleNPJ aging and mechanisms of disease2015
Fine mapping the
Open access · goldAbstract read
In one paragraph
Article in NPJ aging and mechanisms of disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 24% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Case Report: Exceptional longevity in turner syndrome.Frontiers in aging · 2026Article
- Bayesian LASSO for population stratification correction in rare haplotype association studies.Statistical applications in genetics and molecular biology · 2024Article
- Population stratification correction using Bayesian shrinkage priors for genetic association studies.Annals of human genetics · 2023Article
- Changes in the Prevalence of Metabolic Syndrome, Its Components, and Relevant Preventive Medication between 2011 and 2018 in the Northeast Hungarian Roma Population.Journal of personalized medicine · 2021Article
- The Association between HDL-C and Subclinical Atherosclerosis Depends on CETP Plasma Concentration: Insights from the IMPROVE Study.Biomedicines · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
90 authors at 20 institutions in 8 countries.
Elisabeth M van LeeuwenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Jennifer E HuffmanMRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK.
Joshua C BisDepartment of Medicine, University of Washington, Seattle, WA, USA.
Aaron IsaacsDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Monique MulderDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Aniko SaboHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Serkalem DemissieDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Ani ManichaikulCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Jennifer A BrodyDepartment of Medicine, University of Washington, Seattle, WA, USA.
Mary F FeitosaDepartment of Genetics, Washington University School of Medicine, St Louis, MO, USA.
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Katharina E SchrautCentre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland.
Pau NavarroMRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK.
Jana V van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Gu ZhuGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Hamdi MbarekDepartment of Biological Psychology, VU University Amsterdam and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
Joris DeelenDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sander W van der LaanDepartment of Experimental Cardiology, UMC Utrecht, Utrecht, The Netherlands.
Gail DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Andrea Jm Vermeij-VerdooldDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Andy Alj van OosterhoutDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Jeannette M Vergeer-DropDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Holly TrochetMRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK.
Generation Scotland
Carolina Medina-GomezDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Andre G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Abbas DehghanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Eric J SijbrandsDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Charles C WhiteProgram in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
Josyf C MychaleckyjCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Gina M PelosoAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Morris A SwertzDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
LifeLines Cohort Study
Gonneke WillemsenDepartment of Biological Psychology, VU University Amsterdam and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
Eco J de GeusDepartment of Biological Psychology, VU University Amsterdam and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
Yuri MilaneschiDepartment of Psychiatry, VU University Medical Center Amsterdam/GGZinGeest and EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
Brenda Wjh PenninxDepartment of Psychiatry, VU University Medical Center Amsterdam/GGZinGeest and EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
Brendan M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
Anton Jm de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
John M StarrDepartment of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Gerard PasterkampLaboratory of Clinical Chemistry and Hematology, Division Laboratories & Pharmacy, UMC Utrecht, Utrecht, the Netherlands.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
P Eline SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Kjell NikusDepartment of Cardiology, Heart Centre, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and University of Tampere School of Medicine, Tampere, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere, Finland.
Jorma S ViikariDivision of Medicine, Turku University Hospital, and Department of Medicine, University of Turku, Turku, Finland.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Jouke-Jan HottengaDepartment of Biological Psychology, VU University Amsterdam and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, VU University Amsterdam and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
John B WhitfieldGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Grant MontgomeryDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
CHARGE Lipids Working Group
Ozren PolasekDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Veronique VitartMRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK.
Caroline HaywardMRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK.
Ivana KolcicDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Alan F WrightMRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK.
Igor RudanCentre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
Peter K JoshiCentre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland.
James F WilsonCentre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland.
Leslie A LangeCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Tamar B HarrisNational Institute on Aging, National Institute of Health, Bethesda, MD, USA.
Alanna C MorrisonHuman Genetics Center, The University of Texas School of Public Health, Houston, TX, USA.
Ingrid B BoreckiDepartment of Genetics, Washington University School of Medicine, St Louis, MO, USA.
Stephen S RichCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Sandosh PadmanabhanDivision of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Bruce M PsatyDepartment of Medicine, Epidemiology & Health Services, University of Washington, Seattle, WA, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Blair H SmithMedical Research Institute, University of Dundee, Dundee, UK.
Eric BoerwinkleHuman Genetics Center, The University of Texas School of Public Health, Houston, TX, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Cornelia van DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Erasmus MC · NLUniversity Medical Center Groningen · NLInstitute of Genetics and Cancer · GBLeiden University Medical Center · NLUniversity of Turku · FIQIMR Berghofer Medical Research Institute · AUAmsterdam Neuroscience · NLBoston University · USUniversity of Iceland · ISAmsterdam Public Health · NLBrigham and Women's Hospital · USBroad Institute · USGroup Health Cooperative · USJackson Memorial Hospital · USNational Institute on Aging · USUniversity College Cork · IEUniversity of Dundee · GBUniversity of Edinburgh · GBUniversity of Split · HRUniversity of Virginia · US
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MChief Scientist Office CZD/16/6/4NCATS NIH HHS UL1 TR000124NIDDK NIH HHS P30 DK063491
Abstract
backgroundIndividuals with exceptional longevity and their offspring have significantly larger high-density lipoprotein concentrations (HDL-C) particle sizes due to the increased homozygosity for the I405V variant in the cholesteryl ester transfer protein (
methodsWe performed a meta-analysis of HDL-C within the
resultsThe meta-analysis of HDL-C within the
conclusionsThe causal variants in
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.