ArticleNPJ biofilms and microbiomes2015
Functional biomarkers for chronic periodontitis and insights into the roles of
Article in NPJ biofilms and microbiomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Microbial signatures in human periodontal disease: a metatranscriptome meta-analysis.Frontiers in microbiology · 2024Pooled it
- Differences in the subgingival microbial population of chronic periodontitis in subjects with and without type 2 diabetes mellitus-a systematic review.Clinical oral investigations · 2018Pooled it
- Article
- The Role of the Oral Microbiome in the Development and Treatment of Periodontal Disease: Functional Meta-Omics Evidence.Current microbiology · 2026Review
- The dual roles ofFrontiers in oncology · 2026Review
- Article
- Four-Week Evaluation of the Interaction Pattern Among Saccharibacteria, Nitrate-Reducing Bacteria, and Periodontopathogens in Orthodontic Miniscrew Implants.Dentistry journal · 2025Article
- Exploring heme and iron acquisition strategies of Porphyromonas gingivalis-current facts and hypotheses.FEMS microbiology reviews · 2025Review
- Advancing periodontitis microbiome research: integrating design, analysis, and technology.Frontiers in cellular and infection microbiology · 2025Review
- Pooled analysis of oral microbiome profiles defines robust signatures associated with periodontitis.mSystems · 2024Article
- Metabolic Footprint ofPathogens (Basel, Switzerland) · 2024Article
- Supra- and Subgingival Microbiome in Gingivitis and Impact of Biofilm Control: A Comprehensive Review.Antibiotics (Basel, Switzerland) · 2024Review
- Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution.Microbiology and molecular biology reviews : MMBR · 2024Review
- Colorimetric detection of oral bacteria using functionalized gold nanoparticles as a plasmonic biosensor array.Nanoscale advances · 2024Article
- Novel bacterial proteolytic and metabolic activity associated with dental erosion-induced oral dysbiosis.Microbiome · 2023Article
- Endogenous and microbial biomarkers for periodontitis and type 2 diabetes mellitus.Frontiers in endocrinology · 2023Review
- The oral bacteriomes of patients with allergic rhinitis and asthma differ from that of healthy controls.Frontiers in microbiology · 2023Article
- Hemophore-like proteins produced by periodontopathogens are recognized by the host immune system and react differentially with IgG antibodies.Journal of oral microbiology · 2023Article
- Oral Microbiota Profile in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.Microorganisms · 2022Article
- Sodium butyrate inhibits osteogenesis in human periodontal ligament stem cells by suppressing smad1 expression.BMC oral health · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesPeriodontitis is the most prevalent inflammatory disease worldwide and is caused by a dysbiotic subgingival biofilm. Here we used metatranscriptomics to determine the functional shift from health to periodontitis, the response of individual species to dysbiosis and to discover biomarkers.
methodsSixteen individuals were studied, from which six were diagnosed with chronic periodontitis. Illumina sequencing of the total messenger RNA (mRNA) yielded ~42 million reads per sample. A total of 324 human oral taxon phylotypes and 366,055 open reading frames from the HOMD database reference genomes were detected.
resultsThe transcriptionally active community shifted from Bacilli and Actinobacteria in health to Bacteroidia, Deltaproteobacteria, Spirochaetes and Synergistetes in periodontitis. Clusters of orthologous groups (COGs) related to carbohydrate transport and catabolism dominated in health, whereas protein degradation and amino acid catabolism dominated in disease. The LEfSe, random forest and support vector machine methods were applied to the 2,000 most highly expressed genes and discovered the three best functional biomarkers, namely haem binding protein HmuY from
conclusionGene biomarkers of periodontitis are highly predictive. The pro-inflammatory role of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.