ArticleNPJ biofilms and microbiomes2015
Effect of electrical energy on the efficacy of biofilm treatment using the bioelectric effect.
Article in NPJ biofilms and microbiomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 80 citations in OpenAlex.
- Evaluation of dental plaque reduction using microcurrent-emitting toothbrushes in orthodontic patients: a randomized, double-blind, crossover clinical trial.Scientific reports · 2024Trial
- Domain shuffling of endolysin LysKB317 to controlBiotechnology reports (Amsterdam, Netherlands) · 2026Article
- Ultrasound-stimulated BTO-BSA-gen inhibits implant-associated infections by suppressing bacterial adhesion and potentiating aminoglycosides.Journal of nanobiotechnology · 2026Article
- Harnessing synthetic circuits to illuminate microbial electron transfer: a perspective on engineered metabolism.Journal of microbiology & biology education · 2026Article
- Comparative effects of bioelectric and manual toothbrushing on acrylic denture teeth: Surface integrity and wear analysis.PloS one · 2026Article
- Smart biomaterials in restorative dentistry: Recent advances and future perspectives.Materials today. Bio · 2025Review
- Engineering an electroactive bacterial cellulose-carbon nanotube composite membrane againstBiofilm · 2025Article
- Electric fields unlock a transient vulnerability window for vancomycin-based treatment of staphylococcal biofilms.Scientific reports · 2025Article
- Antibacterial PEEK-Ag Surfaces: Development and In Vitro Evaluation AgainstJournal of functional biomaterials · 2025Article
- Low-level direct currents eradicate multi-drug-resistantChemical engineering journal (Lausanne, Switzerland : 1996) · 2025Article
- On the effectiveness of electrical characterization of mature Staphylococcal Biofilm.Scientific reports · 2025Article
- Clinical Investigation of Bioelectric Toothbrush for Dentin Hypersensitivity Management: A Randomized Double-Blind Study.Bioengineering (Basel, Switzerland) · 2024Article
- Revealing detrimental effects of various DC electrical energy conditions on different multidrug resistant bacteria: a comprehensive study.Scientific reports · 2024Article
- Comparative Analysis of Plaque Removal and Wear between Electric-Mechanical and Bioelectric Toothbrushes.Bioengineering (Basel, Switzerland) · 2024Article
- Anti-Biofilm Strategies: A Focused Review on Innovative Approaches.Microorganisms · 2024Review
- Multiple biological characteristics and functions of intestinal biofilm extracellular polymers: friend or foe?Frontiers in microbiology · 2024Review
- Bioelectric device for effective biofilm inflammation management of dental implants.Scientific reports · 2023Article
- A Study on the Biofilm Removal Efficacy of a Bioelectric Toothbrush.Bioengineering (Basel, Switzerland) · 2023Article
- Smart dental materials for antimicrobial applications.Bioactive materials · 2023Article
- A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections.Advanced materials (Deerfield Beach, Fla.) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe use of electric fields in combination with small doses of antibiotics for enhanced treatment of biofilms is termed the 'bioelectric effect' (BE). Different mechanisms of action for the AC and DC fields have been reported in the literature over the last two decades. In this work, we conduct the first study on the correlation between the electrical energy and the treatment efficacy of the bioelectric effect on
methodsA thorough study was performed through the application of alternating (AC), direct (DC) and superimposed (SP) potentials of different amplitudes on mature
resultsResults show that there is no statistical difference in treatment efficacy between the DC-, AC- and SP-based BE treatment of equivalent energies (analysis of variance (ANOVA)
conclusionsOur results demonstrate that the energy of the electrical signal, and not the type of electrical signal (AC or DC or SP), is the key to determine the efficacy of the BE treatment. We anticipate that this observation will pave the way for further understanding of the mechanism of action of the BE treatment method and may open new doors to the use of electric fields in the treatment of bacterial biofilms.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.