Evidence map›Paper›PMID 28721154›Full record

ArticleArchives of medical science : AMS2017

Obesity and inflammation: the linking mechanism and the complications.

Mohammed S Ellulu, Ismail Patimah, Huzwah Khaza'ai, Asmah Rahmat, Yehia Abed

4 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of medical science : AMS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 1,089 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,089citing papers in PubMed, 10 pooled it
28.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04360148 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Randomized-controlled Study for Evaluation of Ketogenic Metabolic Nutritional Pattern in Subjects With High-frequency Episodic Migraine

TypeinterventionalSponsorNew Penta SRLRan2020 to 2021Enrolled58ConditionsMigraine, Ketogenic Dieting, Weight Loss, OverweightArmsvery-low-calorie-ketogenic-diet, hypocaloric-balanced-diet
NCT04731831 unknown statusnot on this mapstarted 2020, after this paper: background citation

Characterization of Immunogenicity of Tumor Necrosis Factor Inhibitors in Arthritis Patients With Poorer Treatment Response Due to Gender, Obesity and Smoking Status.

TypeobservationalSponsorAalborg University HospitalRan2020 to 2025Enrolled120ConditionsArthritis, Rheumatoid, Arthritis, Psoriatic, Spondylitis, Ankylosing
NCT06377358 nacompletednot on this mapstarted 2022, after this paper: background citation

Lipolysis of Visceral Reserve Fat Using Tecar Therapy: Anthropometric, Biochemical and NMR Imaging Study.

TypeinterventionalSponsorCAPENERGY MEDICAL, SLRan2022 to 2023Enrolled20ConditionsObesity, Visceral, Obesity, EndocrineArmsTecar Therapy
NCT06915558 recruitingnot on this mapstarted 2024, after this paper: background citation

Modulation of the Inflammatory Response to Surgical Trauma: Comparison of Three Anesthetic Techniques in Bariatric Surgery Patients

TypeobservationalSponsorHospital HM Nou DelfosRan2024 to 2025Enrolled90ConditionsObesity, Bariatric Surgery Candidate, Inflammation, Postoperative PainArmsOpioid-Free Anesthesia (OFA), Opioid-Based Intravenous Anesthesia (OBA-IV), Opioid-Based Inhalational Anesthesia (OBA-Inh)
3 · Its place in the literature

Who cites it

1,089 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,890 citations in OpenAlex.

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  6. Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
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  18. Gut microbes · 2026
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1,029 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Mohammed S ElluluDepartment of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang, Malaysia.
Ismail PatimahDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang, Malaysia.
Huzwah Khaza'aiDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang, Malaysia.
Asmah RahmatCancer Resource and Educational Centre (CARE), Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Malaysia.
Yehia AbedFaculty of Public Health, Al Quds University of Gaza, Palestine.
Universiti Putra Malaysia · MYFaculty of Public Health · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus. It is also associated with development of non-cardiovascular diseases such as psoriasis, depression, cancer, and renal diseases. On the other hand, a reduced level of adiponectin, a significant predictor of cardiovascular mortality, is associated with impaired fasting glucose, leading to type-2 diabetes development, metabolic abnormalities, coronary artery calcification, and stroke. Finally, managing obesity can help reduce the risks of cardiovascular diseases and poor outcome via inhibiting inflammatory mechanisms.

Indexed as

adiponectinC reactive proteininflammationinterleukin 6linking mechanismobesity

Identifiers

PMID28721154
PMCPMC5507106
OpenAlexW2405624971

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.