ArticleArchives of medical science : AMS2017
The effect of antihypertensive treatment on arterial stiffness and serum concentration of selected matrix metalloproteinases.
Article in Archives of medical science : AMS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Four-dimensional analysis of aortic root motion in normal population using retrospective multiphase computed tomography.European heart journal. Imaging methods and practice · 2024Article
- Matrix Metalloproteinases in Cardioembolic Stroke: From Background to Complications.International journal of molecular sciences · 2023Review
- Association of spironolactone treatment and arterial stiffness and cardiovascular disease in hypertensive patients.Archives of medical science : AMS · 2022Article
- MMPs and TIMPs levels are correlated with anthropometric parameters, blood pressure, and endothelial function in obesity.Scientific reports · 2021Article
- Serum MMP-3 and its association with central arterial stiffness among young adults is moderated by smoking and BMI.Physiological reports · 2021Article
- The association of endothelin-1 gene polymorphism and its plasma levels with hypertension and coronary atherosclerosis.Archives of medical science : AMS · 2021Article
- Inflammaging as a link between autoimmunity and cardiovascular disease: the case of rheumatoid arthritis.RMD open · 2021Review
- Systolic stretching of the ascending aorta.Archives of medical science : AMS · 2021Article
- Thiazide Diuretic-Induced Change in Fasting Plasma Glucose: a Meta-analysis of Randomized Clinical Trials.Journal of general internal medicine · 2020Review
- Matrix Metalloproteinases and Hypertension-Mediated Organ Damage: Current Insights.Integrated blood pressure control · 2020Review
- Effects of blood pressure goals on cardiovascular outcomes in hypertensive patients.Archives of medical science : AMS · 2019Article
- Hypertension-induced subclinical vascular and cognitive changes are reversible-An observational cohort study.Journal of clinical hypertension (Greenwich, Conn.) · 2019Observational
- Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia.Journal of Zhejiang University. Science. BArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of the study was to assess the arterial stiffness and serum levels of selected metalloproteinases (MMPs) in hypertensive patients and their changes following antihypertensive therapy. MATERIAL AND
methodsThe study group consisted of 95 patients with essential arterial hypertension (HT) stage 1 or 2 (mean age: 53.1 ±13.0 years). The control group consisted of 31 normotensives of the same age range. Hypertension patients were randomized to one of the following monotherapies for 6 months: quinapril, losartan, amlodipine, hydrochlorothiazide or bisoprolol. Carotid-femoral pulse wave velocity (PWV) was measured using a Complior device. Serum concentrations of MMPs (proMMP-1, MMP-2, MMP-3, MMP-9) and plasma concentration of tissue inhibitor of MMPs (TIMP-1) were measured using ELISA.
resultsPulse wave velocity and serum concentrations of MMP-2 and MMP-9 were higher in HT patients than in the control group. In HT patients PWV was significantly associated (
conclusionsIn patients with arterial hypertension, beside age and systolic blood pressure, the determinants of arterial stiffness include serum MMP-3 concentration. For drugs compared in the study with the same hypotensive effect obtained, the arterial stiffness reduction effect is not dependent on the drug used. Systolic blood pressure is one of the independent factors responsible for the reduction of arterial stiffness in the course of antihypertensive treatment.
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