ReviewJournal of asthma and allergy2017
Food protein-induced enterocolitis syndrome - a review of the literature with focus on clinical management.
Review in Journal of asthma and allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Food protein-induced enterocolitis syndrome in children: An updated review on pathogenesis, diagnosis, and management.World journal of clinical pediatrics · 2026Review
- Food Protein-Induced Enterocolitis Syndrome Across Lifespan: Focus on Adolescence.Journal of clinical medicine · 2025Review
- Bovine Colostrum in Pediatric Nutrition and Health.Nutrients · 2024Review
- Cow's milk protein allergy in infants and children.Paediatrics & child health · 2024Review
- L'allergie aux protéines du lait de vache chez les nourrissons et les enfants.Paediatrics & child health · 2024Review
- Delayed presentation of food protein-induced enterocolitis syndrome (FPIES) to okra in a toddler.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Article
- Pearls and pitfalls in food protein-induced enterocolitis syndrome (FPIES).Allergy and asthma proceedings · 2023Review
- Perspectives on Non-IgE-Mediated Gastrointestinal Food Allergy in Pediatrics: A Review of Current Evidence and Guidelines.Journal of asthma and allergy · 2023Review
- Diagnostic and Management Strategies of Food Protein-Induced Enterocolitis Syndrome: Current Perspectives.Pediatric health, medicine and therapeutics · 2023Review
- The Role of the Gallbladder, the Intestinal Barrier and the Gut Microbiota in the Development of Food Allergies and Other Disorders.International journal of molecular sciences · 2022Review
- Food protein-induced enterocolitis syndrome with pneumatosis intestinalis in an exclusively breastfed infant: A case report and literature review.Clinical case reports · 2022Article
- Food protein-induced enterocolitis syndrome in a tertiary pediatric center: safety of guideline-conforming food challenges.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Modified oral food challenge protocol approach in the diagnosis of Food Protein-Induced Enterocolitis Syndrome.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Hydrolysed Formulas in the Management of Cow's Milk Allergy: New Insights, Pitfalls and Tips.Nutrients · 2021Review
- Review
- Food Protein-Induced Enterocolitis Syndrome: a Comprehensive Review.Clinical reviews in allergy & immunology · 2019Review
- A 4-month-old girl with hematemesis, pallor, and lethargy.Paediatrics & child health · 2019Article
- The role of mast cells in pediatric gastrointestinal disease.Annals of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Food protein-induced enterocolitis syndrome (FPIES) is a potentially severe presentation of non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) with heterogeneous clinical manifestations. Acute FPIES is typically characterized by profuse vomiting and lethargy, occurring classically 1-4 hours after ingestion of the offending food. When continuously exposed to the incriminated food, a chronic form has been described with persistent vomiting, diarrhea, and/or failure to thrive. Although affecting mainly infants, FPIES has also been described in adults. Although FPIES is actually one of the most actively studied non-IgE-GI-FAs, epidemiologic data are lacking, and estimation of the prevalence is based on a limited number of prospective studies. The exact pathomechanisms of FPIES remain not well defined, but recent data suggest involvement of neutrophils and mast cells, in addition to T cells. There is a wide range of food allergens that can cause FPIES with some geographical variations. The most frequently incriminated foods are cow milk, soy, and grains in Europe and USA. Furthermore, FPIES can be induced by foods usually considered as hypoallergenic, such as chicken, potatoes or rice. The diagnosis relies currently on typical clinical manifestations, resolving after the elimination of the offending food from the infant's/child's diet and/or an oral food challenge (OFC). The prognosis is usually favorable, with the vast majority of the case resolving before 5 years of age. Usually, assessment of tolerance acquisition by OFC is proposed every 12-18 months. Of note, a switch to an IgE-mediated FA is possible and has been suggested to be associated with a more severe phenotype. Avoiding the offending food requires education of the family of the affected child. A multidisciplinary approach including ideally allergists, gastroenterologists, dieticians, specialized nurses, and caregivers is often useful to optimize the management of these patients, that might be difficult.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.