ArticleNeuropsychiatric disease and treatment2017
Reduced prefrontal activation during verbal fluency task in chronic insomnia disorder: a multichannel near-infrared spectroscopy study.
Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
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- Task-induced hyperfunction of the left dorsolateral prefrontal cortex in patients with primary insomnia: a near-infrared spectroscopy study during a verbal fluency task.Frontiers in psychiatry · 2026Article
- Cortical activation and functional connectivity during verbal fluency task in patients with chronic insomnia: a multi-channel fNIRS study.Scientific reports · 2025Article
- Relationship between cortical activation and sleep quality in cerebral small vessel disease patients: a functional near-infrared spectroscopy (fNIRS) study.Frontiers in neurology · 2025Article
- Changes in temporal lobe activation during a sound stimulation task in patients with sensorineural tinnitus: a multi-channel near-infrared spectroscopy study.Biomedical engineering online · 2024Article
- The impact of sleep disorders on brain network connectivity in postpartum women: a functional near-infrared spectroscopy-based study.Frontiers in neurology · 2024Article
- Neurological activation during verbal fluency task and resting-state functional connectivity abnormalities in obsessive-compulsive disorder: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2024Article
- Correlation analysis between insomnia symptoms and language function in patients with schizophrenia.Schizophrenia research. Cognition · 2023Article
- Insomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patients.BMC psychiatry · 2023Article
- Abnormal Prefrontal Brain Activation During a Verbal Fluency Task in Treatment-Resistant Depression Using Near-Infrared Spectroscopy.Psychiatry investigation · 2023Article
- Altered electrophysiology mechanism related to inhibitory control in adults with insomnia.Frontiers in neurology · 2023Article
- The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task.Frontiers in psychiatry · 2023Article
- Prefrontal cortex functional connectivity changes during verbal fluency test in adults with short-term insomnia disorder: a functional near-infrared spectroscopy study.Frontiers in neuroscience · 2023Article
- Article
- Executive functioning and verbal fluency performance in youth with Down syndrome.Research in developmental disabilities · 2022Article
- Prefrontal brain function in patients with chronic insomnia disorder: A pilot functional near-infrared spectroscopy study.Frontiers in neurology · 2022Article
- Low-Frequency Magnetic Stimulation of Shenmen Acupoint Reduces Blood Oxygen Levels in the Prefrontal Cortex of Healthy Subjects: A Near-Infrared Brain Functional Imaging Study.Chinese journal of integrative medicine · 2021Article
- Affect and Arousal in Insomnia: Through a Lens of Neuroimaging Studies.Current psychiatry reports · 2020Review
- Acceptance and commitment therapy for nurses' sleep, rumination, psychological flexibility, and it's neural mechanism: A randomized controlled fNIRS study.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDaytime complaints such as memory and attention deficits and failure to accomplish daily tasks are common in insomnia patients. However, objective psychological tests to detect cognitive impairment are equivocal. Neural function associated with cognitive performance may explain the discrepancy. The aim of this study was to investigate the hemodynamic response patterns of patients with chronic insomnia disorder (CID) using the noninvasive and low-cost functional neuroimaging technique of multichannel near-infrared spectroscopy (NIRS) in order to identify changes of neural function associated with cognitive performance. PATIENTS AND
methodsTwenty-four CID patients and twenty-five healthy controls matched for age, right-hand dominance, educational level, and gender were examined during verbal fluency tasks (VFT) using NIRS. A covariance analysis was conducted to analyze differences of oxygenated hemoglobin (oxy-Hb) changes in prefrontal cortex (PFC) between the two groups and reduce the influence of the severity of depression. Pearson correlation coeffcients were calculated to examine the relationship between the oxy-Hb changes, with the severity of insomnia and depressive symptoms assessed by the Pittsburgh Sleep Quality Index (PSQI) and the Hamilton Rating Scale for Depression (HAMD).
resultsThe number of words generated during the VFT in CID groups showed no statistical differences with healthy controls. CID patients showed hypoactivation in the PFC during the cognitive task. In addition, we found that the function of left orbitofrontal cortex (OFC) during the VFT was significantly negatively correlated with the PSQI scores and the function of right dorsolateral PFC (DLPFC) was significantly negatively correlated with the HAMD scores.
conclusionThe present study detected dysfunctions in PFC in spite of intact performance which indicates the role of PFC in the neurophysiological underpinnings. Left OFC function is associated with insomnia symptoms and right DLPFC function is associated with depressive symptoms.
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