ArticleClinical interventions in aging2017
Frequency of frailty and its association with cognitive status and survival in older Chileans.
Article in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Global Prevalence of Cognitive Frailty in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2026Pooled it
- Association of frailty and mortality risk in community-dwelling older adults: a systematic review and meta-analysis of 59 international prospective cohort studies.BMC public health · 2026Pooled it
- Geriatric and cardiometabolic syndromes in older adults with sarcopenic obesity: a comparative cross-sectional study with sarcopenia and obesity.BMC geriatrics · 2026Article
- Association between malnutrition and cognitive decline in Chinese older adults: the mediating role of physical frailty.Frontiers in public health · 2026Article
- Urban Quality and Biochemical, Hematological, and Nutritional Markers in Older Adults: Cross-Sectional Geospatial Study.JMIR aging · 2025Article
- An mHealth App (NeoMayor) to Promote Healthy Lifestyles and Brain Health in Older Adults: Design and Validation Study.JMIR aging · 2025Article
- The cross-sectional relationship of physical frailty and cognitive impairment in older Poles: analysis of the PolSenior2 data.European geriatric medicine · 2025Article
- Article
- Subjective cognitive decline-a neglected but preventable public health concern: development and validation of a risk prediction model for subjective cognitive decline in older adults: a cross-sectional survey study from Anhui Province in eastern China.Frontiers in public health · 2025Article
- Self-Reported Sleep Duration Is a Useful Tool to Predict Sarcopenia in Chilean Older Adults: Evidence from the ALEXANDROS Longitudinal Study.Journal of personalized medicine · 2024Article
- RhoA/rho kinase pathway activation in age-associated endothelial cell dysfunction and thrombosis.Journal of cellular and molecular medicine · 2024Review
- Association between disability and cognitive function in older Chinese people: a moderated mediation of social relationships and depressive symptoms.Frontiers in public health · 2024Article
- Decreased mitochondrial respiration associates with frailty in community-dwelling older adults.Frontiers in cell and developmental biology · 2024Article
- Sex-modified association between grip strength and mild cognitive impairment: a cross-sectional and follow-up study in rural China.BMC geriatrics · 2023Article
- Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults.International journal of environmental research and public health · 2023Article
- The Impact of a Yoga-Based Mindfulness Intervention versus Psycho-Educational Session for Older Adults with Mild Cognitive Impairment: The Protocol of a Randomized Controlled Trial.International journal of environmental research and public health · 2022Article
- Characterization by Gender of Frailty Syndrome in Elderly People according to Frail Trait Scale and Fried Frailty Phenotype.Journal of personalized medicine · 2022Article
- Deficit Accumulation Frailty Trajectories of Older Breast Cancer Survivors and Non-Cancer Controls: The Thinking and Living With Cancer Study.Journal of the National Cancer Institute · 2021Article
- Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure.Scientific reports · 2021Article
- Sex- and age-specific mild cognitive impairment is associated with low hand grip strength in an older Chinese cohort.The Journal of international medical research · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAge-associated brain physiologic decline and reduced mobility are key elements of increased age-associated vulnerability.
objectiveTo study the frequency of frailty phenotype and its association with mental health and survival in older Chileans.
methodsFollow-up of ALEXANDROS cohorts designed to study disability associated with obesity in community-dwelling people 60 years and older living in Santiago, Chile. At baseline, 2,098 (67% women) of 2,372 participants had the necessary measurements for the identification of the frailty phenotype: weak handgrip dynamometry, unintentional weight loss, fatigue/exhaustion, five chair-stands/slow walking speed and difficulty walking (low physical activity). After 10-15 years, 1,298 people were evaluated and 373 had died. Information regarding deaths was available for the whole sample.
resultsThe prevalence of frailty at baseline (≥3 criteria) in the whole sample was 13.9% (women 16.4%; men 8.7%) and the pre-frailty prevalence (1-2 criteria) was 63.8% (65.0% vs 61.4%), respectively. Frailty was associated with cognitive impairment (frail 48.1%; pre-frail 21.7%; nonfrail 20.5%,
conclusionFrailty is highly prevalent and strongly associated with cognitive impairment and depression in older Chileans. The risk for death was higher for frail people, but underlying cognitive impairment is a key component of the lower survival rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.