ArticleDrug design, development and therapy2017
Effect of picroside II on hind limb ischemia reperfusion injury in rats.
Article in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- The effect of quercetin on ischemia-reperfusion injury in skeletal muscle in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Melatonin as a shield against skeletal muscle damage: A study on ischemia-reperfusion injury.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- Therapeutic Potential of Carnosine in Ischemia-Reperfusion Injury: A Preclinical Study in Muscle Tissue.Cardiology research and practice · 2025Article
- Advances in the treatment of lower-extremity ischemia-reperfusion injury.Frontiers in pharmacology · 2025Review
- Clinical rationale for dietary lutein supplementation in long COVID and mRNA vaccine injury syndromes.F1000Research · 2024Review
- The Evaluation of Oxidative Stress in the Young Adults with COVID-19 mRNA Vaccines Induced Acute Pericarditis- Myopericarditis.International journal of general medicine · 2022Article
- Laboratory and Imaging Evaluation of Cardiac Involvement in Patients with Post-Acute COVID-19.International journal of general medicine · 2021Article
- Irisin Protects Against Hind Limb Ischemia Reperfusion Injury.Drug design, development and therapy · 2021Article
- Effects of N-Acetylcysteine and N-Acetylcysteine Amide on Erythrocyte Deformability and Oxidative Stress in a Rat Model of Lower Extremity Ischemia-Reperfusion Injury.Cardiology research and practice · 2020Article
- An integrative approach to develop computational pipeline for drug-target interaction network analysis.Scientific reports · 2018Article
- Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?Drug design, development and therapy · 2018Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMany structural and functional damages are observed in cells and tissues after reperfusion of previously viable ischemic tissues. Acute ischemia reperfusion (I/R) injury of lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Research regarding the treatment of I/R injury has been increasing day-by-day. In this study, we aimed to investigate the effect of picroside II on skeletal muscle of rats experiencing simulated I/R. MATERIALS AND
methodsTwenty-four male Wistar albino rats weighing between 210 and 300 g were used in this study. Rats were randomly divided into 4 groups of 6 rats each (control, I/R, control + picroside II, and I/R + picroside II). The infrarenal section of the abdominal aorta was occluded with an atraumatic microvascular clamp in I/R group. The clamp was removed after 120 minutes and reperfusion was provided for a further 120 minutes. Picroside II (10 mg kg
resultsTOS levels were significantly higher in I/R group than that of control and I/R + picroside II groups (
conclusionThe results of this study demonstrated that picroside II plays a critical role to prevent I/R injury. Even though our results were found to be satisfactory, it should be encouraging to those who want to conduct future research on this topic.
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