ArticleScientific reports2017
Adhesion of Toxoplasma gondii tachyzoite-infected vehicle leukocytes to capillary endothelial cells triggers timely parasite egression.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed.
- May bacterial meningitis pave the way for a toxoplasmosis flare-up: a cross-sectional study from Egypt.BMC infectious diseases · 2025Article
- Human Brain Endothelial Cell-Derived Extracellular Vesicles ReduceInternational journal of molecular sciences · 2025Article
- Review
- Visualization of parasite dynamics in the host tissues: application of tissue transparency technology to parasite research.The Journal of veterinary medical science · 2023Review
- Blood-brain barrier-restricted translocation ofeLife · 2021Article
- Congenital Transmission of Apicomplexan Parasites: A Review.Frontiers in microbiology · 2021Review
- Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity.PLoS pathogens · 2020Article
- Early Kinetics of Intestinal Infection and Immune Responses to TwoFrontiers in cellular and infection microbiology · 2020Article
- CNS Macrophages and Infant Infections.Frontiers in immunology · 2020Review
- The hitchhiker's guide to parasite dissemination.Cellular microbiology · 2019Review
- CD40 in Endothelial Cells Restricts Neural Tissue Invasion by Toxoplasma gondii.Infection and immunity · 2019Article
- Epidermal growth factor receptor promotes cerebral and retinal invasion by Toxoplasma gondii.Scientific reports · 2019Article
- Calling in the CaFrontiers in cellular and infection microbiology · 2019Review
- Advances and Challenges in Understanding Cerebral Toxoplasmosis.Frontiers in immunology · 2019Review
- Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity.European journal of immunology · 2018Review
- False friends: Phagocytes as Trojan horses in microbial brain infections.PLoS pathogens · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular pathogens have numerous strategies for effective dissemination within the host. Many intracellular pathogens first infect leukocytes, which they use as a vehicle to transport them to target organs. Once at the target organ, intracellular parasite Toxoplasma gondii can cross the capillary wall in extracellular form by infecting endothelial cells. However, after egression from leukocytes, extracellular parasites face the risk of host immune attack. In this study, observation of infected mouse organs, using a method that renders tissue transparent, revealed that adhesion of tachyzoite-infected leukocytes to endothelial cells triggers immediate egression of the parasite. This signal enables the parasite to time egression from its vehicle leukocyte to coincide with arrival at a target organ, minimizing the opportunity for immune attack during the transition from a vehicle leukocyte to capillary endothelial cells.
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