ArticleScientific reports2017
Biofilm formation in enterococci: genotype-phenotype correlations and inhibition by vancomycin.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Association of virulence genes with biofilm formation in clinical Enterococcus faecalis isolates: a systematic review and meta-analysis.Archives of microbiology · 2026Pooled it
- Prevalence of Vancomycin resistant enterococci (VRE) in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2020Pooled it
- 3-Hydroxyflavone Inhibits Biofilm Formation and Enhances Antibiotic Activity AgainstAntibiotics (Basel, Switzerland) · 2026Article
- Prevalence, antimicrobial resistance, and virulence factors of Enterococcus spp. infecting broiler chickens in Egypt.Scientific reports · 2026Article
- Gastrodin Inhibits Bacterial Biofilm Formation, Thereby Activating the Antibacterial Activity of Antibiotics.Molecules (Basel, Switzerland) · 2026Article
- Genetic diversity, antimicrobial resistance, and biofilm-associated virulence in clinical Enterococcus faecalis isolates from Hamedan, Iran.BMC infectious diseases · 2026Article
- Evaluation of the antibacterial activity of Akkermansia muciniphila extract against Enterococcus faecium isolates.Molecular biology reports · 2026Article
- Biofilm Formation, Virulence Traits, and Antimicrobial Resistance Profiles ofInternational journal of microbiology · 2026Article
- Unusual susceptibility to vancomycin inFrontiers in microbiology · 2026Review
- Article
- A Novel Agro-Waste Formulated Medium Enhanced the Growth of Electrogenic Enterobacter Species Isolated Using Microbial Fuel Cell System: Response Surface Methodology Approach.Environmental microbiology reports · 2025Article
- Comparative analysis of vancomycin-resistant enterococci in colonization and infection-a longitudinal study.Microbiology spectrum · 2025Article
- Disruption of MRSA Biofilm and Virulence by Deep-Sea Probiotics: Impacts on Energy metabolism and Host Antimicrobial Peptides.Probiotics and antimicrobial proteins · 2025Article
- Comparative Genomic Analysis and Antimicrobial Resistance Profile ofVeterinary sciences · 2025Article
- Molecular Characterization of Vancomycin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Synergistic efficacy of phages along with vancomycin for eradication of vancomycin-resistantWorld journal of virology · 2025Article
- Management of Enterococcus faecalis biofilms: a combinatorial approach with phytochemical.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Molecular characterization of histidine and tyrosine decarboxylating Enterococcus species isolated from some milk products.BMC microbiology · 2025Article
- High-Risk VREfm Clones and Resistance Determinants in a Thai Hospital.Antibiotics (Basel, Switzerland) · 2025Article
- Biofilms and antibiotic resistance profile of Enterococcus faecalis in selected dairy cattle farm environments in Bangladesh.PloS one · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterococci are nosocomial pathogens that can form biofilms, which contribute to their virulence and antibiotic resistance. Although many genes involved in biofilm formation have been defined, their distribution among enterococci has not been comprehensively studied on a genome scale, and their diagnostic ability to predict biofilm phenotypes is not fully established. Here, we assessed the biofilm-forming ability of 90 enterococcal clinical isolates. Major patterns of virulence gene distribution in enterococcal genomes were identified, and the differentiating virulence genes were screened by polymerase chain reaction (PCR) in 31 of the clinical isolates. We found that detection of gelE in Enterococcus faecalis is not sufficient to predict gelatinase activity unless fsrAB, or fsrB alone, is PCR-positive (P = 0.0026 and 0.0012, respectively). We also found that agg is significantly enriched in isolates with medium and strong biofilm formation ability (P = 0.0026). Additionally, vancomycin, applied at sub minimal inhibitory concentrations, inhibited biofilm in four out of five strong biofilm-forming isolates. In conclusion, we suggest using agg and fsrB genes, together with the previously established gelE, for better prediction of biofilm strength and gelatinase activity, respectively. Future studies should explore the mechanism of biofilm inhibition by vancomycin and its possible use for antivirulence therapy.
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