ArticleScientific reports2017
Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Multiparametric MRI: can we assess renal function differently?Clinical kidney journal · 2025Review
- Advances in imaging techniques to assess kidney fibrosis.Renal failure · 2023Review
- MiR-29b modulates DNA methylation in promoter region of miR-130b in mouse model of Diabetic nephropathy.Journal of diabetes and metabolic disorders · 2023Article
- Alterations of Renal Function in Patients with Diabetic Kidney Disease: A BOLD and DTI Study.Computational intelligence and neuroscience · 2022Article
- Study of renal parenchymal changes by diffusion tensor imaging in diabetic nephropathy.Polish journal of radiology · 2022Article
- Correlation between Blood Oxygen Level-Dependent Magnetic Resonance Imaging Images and Prognosis of Patients with Multicenter Diabetic Nephropathy on account of Artificial Intelligence Segmentation Algorithm.Computational and mathematical methods in medicine · 2022Article
- Perspectives on the Role of Magnetic Resonance Imaging (MRI) for Noninvasive Evaluation of Diabetic Kidney Disease.Journal of clinical medicine · 2021Review
- Renal Diffusion-Weighted Imaging (DWI) for Apparent Diffusion Coefficient (ADC), Intravoxel Incoherent Motion (IVIM), and Diffusion Tensor Imaging (DTI): Basic Concepts.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway.Scientific reports · 2020Article
- Magnetic resonance elastography-derived stiffness of the kidneys and its correlation with water perfusion.NMR in biomedicine · 2020Article
- Multiparametric magnetic resonance imaging shows promising results to assess renal transplant dysfunction with fibrosis.Kidney international · 2020Article
- Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques.Translational research : the journal of laboratory and clinical medicine · 2019Review
- Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- MicroRNAs associated with the development of kidney diseases in humans and animals.Journal of toxicologic pathology · 2018Review
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal fibrosis (RF) is an indicator for progression of chronic kidney disease (CKD). Although diabetic nephropathy (DN) is the leading cause of CKD and end-stage renal disease in Western populations, the ability of MRI to evaluate RF in DN patients has not been determined. As a first step to identify possible MRI methods for RF evaluation, we examined the use of diffusion tensor imaging (DTI) MRI to evaluate RF in a rat model of DN (SHR/NDmcr-cp(cp/cp): SHR/ND). The signal-to-noise ratio in DTI MRI was enhanced using a spin-echo sequence, and a special kidney attachment was developed for long-term stabilization. The changes in renal temperature and blood flow during measurement were minimal, suggesting the feasibility of this method. At 38 weeks of age, RF had aggressively accumulated in the outer stripe (OS) of the outer medulla. FA maps showed that this method was successful in visualizing and evaluating fibrosis in the OS of the SHR/ND rat kidney (r = 0.7697, P = 0.0126). Interestingly, in the FA color maps, the directions of water molecule diffusion in RF were random, but distinct from conventional water diffusion in brain neuron fibers. These findings indicate that DTI MRI may be able to evaluate RF in CKD by DN.
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