ArticlemBio2017
A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in
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In one paragraph
Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Repurposing FDA-Approved Drugs to Inhibit Fungal PPTases for Broad-Spectrum Synergy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Characterization of a unique phosphopantetheinyl transferase (PPTase) in the fish pathogen Pseudomonas plecoglossicida.PloS one · 2026Article
- Effects of rumen-protected lysine on antler growth performance, fecal bacterial community, and blood gene expression in sika deer.Frontiers in veterinary science · 2025Article
- The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins.EMBO reports · 2023Article
- Directed Evolution of the BpsA Carrier Protein Domain for Recognition by Non-cognate 4'-Phosphopantetheinyl Transferases to Enable Inhibitor Screening.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Epipolythiodioxopiperazine-Based Natural Products: Building Blocks, Biosynthesis and Biological Activities.Chembiochem : a European journal of chemical biology · 2022Review
- Review
- Escherichia coli Nissle 1917 secondary metabolism: aryl polyene biosynthesis and phosphopantetheinyl transferase crosstalk.Applied microbiology and biotechnology · 2021Article
- Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus.Microbiology spectrum · 2021Article
- Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the EssentialPharmaceutics · 2021Article
- Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates ofbioRxiv : the preprint server for biology · 2020Article
- RELATe enables genome-scale engineering in fungal genomics.Science advances · 2020Article
- Article
- Fumagillin, a Mycotoxin ofToxins · 2019Review
- Screening and Antifungal Activity of aInternational journal of microbiology · 2019Article
- Phosphopantetheinyl transferase (Ppt)-mediated biosynthesis of lysine, but not siderophores or DHN melanin, is required for virulence of Zymoseptoria tritici on wheat.Scientific reports · 2018Article
- Potential targets for the development of new antifungal drugs.The Journal of antibiotics · 2018Review
- Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus.Virulence · 2018Article
- Evolution and Diversity of Biosynthetic Gene Clusters inFrontiers in microbiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Anna JohnsManchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom.
Daniel H ScharfDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Fabio GsallerManchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom.
Hella SchmidtDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Thorsten HeinekampDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Maria StraßburgerTransfer Group Anti-Infectives, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Jason D OliverF2G Ltd., Eccles, Manchester, United Kingdom.
Mike BirchF2G Ltd., Eccles, Manchester, United Kingdom.
Nicola BeckmannF2G Ltd., Eccles, Manchester, United Kingdom.
Katharine S DobbF2G Ltd., Eccles, Manchester, United Kingdom.
Jane GilsenanManchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom.
Bharatkumar RashManchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom.
Elaine BignellManchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom.
Axel A BrakhageDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany axel.brakhage@leibniz-hki.de mike.bromley@manchester.ac.uk.
Michael J BromleyManchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom axel.brakhage@leibniz-hki.de mike.bromley@manchester.ac.uk.
University of Manchester · GBLeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEFriedrich Schiller University Jena · DE
Funding
Medical Research Council G0501164Medical Research Council MC_PC_13070Medical Research Council MR/L000822/1Medical Research Council MR/M02010X/1
Abstract
Secondary metabolites are key mediators of virulence for many pathogens.
Indexed as
AnimalsAspergillosisAspergillus fumigatusBacterial ProteinsBiological FactorsDisease Models, AnimalInsectaLysineMiceSecondary MetabolismSiderophoresTransferases (Other Substituted Phosphate Groups)Virulence FactorsBacterial ProteinsBiological FactorsLysinephosphopantetheinyl transferaseSiderophoresTransferases (Other Substituted Phosphate Groups)Virulence Factorsantifungal agentsAspergillus fumigatusdrug targetsgliotoxinsecondary metabolismvirulence determinants
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.