Evidence map›Paper›PMID 28720729›Full record

ArticlemBio2017

Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD

Dóra Hancz, Elsa Westerlund, Benedicte Bastiat-Sempe, Onkar Sharma, Christine Valfridsson, Lena Meyer, John F Love, Maghnus O'Seaghdha, Michael R Wessels, Jenny J Persson

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Lysosomal permeabilization by Group AInfection and immunity · 2026
    Article
  2. Article
  3. Interplay between group AMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Playing With Fire: Proinflammatory Virulence Mechanisms of Group AFrontiers in cellular and infection microbiology · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. A Prognostic Model of Persistent Bacteremia and Mortality in Complicated Staphylococcus aureus Bloodstream Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Observational
  14. Article
  15. Group AFrontiers in cellular and infection microbiology · 2019
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Cytotoxicity and Survival Fitness of InvasiveFrontiers in microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Dóra HanczImmunology Section, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.
Elsa WesterlundImmunology Section, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.
Benedicte Bastiat-SempeDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Onkar SharmaDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Christine ValfridssonImmunology Section, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.
Lena MeyerImmunology Section, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.
John F LoveDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Maghnus O'SeaghdhaDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Michael R WesselsDivision of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Jenny J PerssonImmunology Section, Department of Experimental Medical Sciences, Lund University, Lund, Sweden jenny_j.persson@med.lu.se.
Lund University · SEHarvard University · USBoston Children's Hospital · US

Funding

IMMUNE RESPONSE TO THE GROUP A STREPTOCOCCAL CAPSULER01AI029952 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI WESSELS, MICHAEL R · 1991 to 2019
$5.6M
Virulence mechanisms of group A streptococcal toxinsR01AI070926 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WESSELS, MICHAEL R · 2008 to 2011
$1.5M
Virulence mechanisms of group A streptococcal toxinsR56AI070926 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WESSELS, MICHAEL R · 2014 to 2014
$440k
NIAID NIH HHS R01 AI029952NIAID NIH HHS R01 AI070926NIAID NIH HHS R56 AI070926
6 · The paper itself

Abstract

Group A

Indexed as

Host-Pathogen InteractionsAnimalsCells, CulturedHumansImmune EvasionInflammasomesInterleukin-1betaMacrophagesMice, Inbred C57BLNAD+ NucleosidaseStreptococcus pyogenesVirulence FactorsInflammasomesInterleukin-1betaNAD+ NucleosidaseVirulence Factorshost-pathogen interactionsimmune regulationinnate immunityStreptococcus pyogenes

Identifiers

PMID28720729
PMCPMC5516252
OpenAlexW2738316966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.