ArticleCirculation2017
Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair.
Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05361772 (Low-dose Colchicine Inhibit Abdominal Aortic Aneurysm Growth Trial), which is not on this map. Cited by 95 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low-dose Colchicine Inhibit Abdominal Aortic Aneurysm Growth Trial
Who cites it
95 citing papers in PubMed.
- n-3 PUFAs improve erythrocyte fatty acid profile in patients with small AAA: a randomized controlled trial.Journal of lipid research · 2019Trial
- Frailty and prefrailty are associated with increased risk of aortic aneurysm but not aortic dissection: a prospective cohort study of UK biobank participants.BMC cardiovascular disorders · 2026Article
- Simultaneous Volumetric T1 and T2 Mapping With Blood- and Fat-Suppression in Abdominal Aortic Aneurysms.Magnetic resonance in medicine · 2026Article
- Longitudinal 4D Flow MRI-Derived Wall Shear Stress in Patients With an Abdominal Aortic Aneurysm.Journal of magnetic resonance imaging : JMRI · 2026Article
- MMP-Activated Liposomal Nanoplatform Co-loaded with Kaempferol and ICG for Targeted Imaging and Therapy of Abdominal Aortic Aneurysm.ACS applied materials & interfaces · 2026Article
- MSC-EVs Prevent Abdominal Aortic Aneurysm Formation by Inhibiting Perivascular Adipose Tissue-Induced NET Release.Stem cells international · 2026Article
- Multifunctional nanoparticles in abdominal aortic aneurysm management: from basic research to clinical transformation.Journal of nanobiotechnology · 2025Review
- Application of Biomimetic SPIONs in Targeted Lung Cancer Therapy: Cell-Membrane Camouflage Technology and Lung Retention Enhancement Strategies.Pharmaceutics · 2025Review
- Association between perivascular fat density on CT angiography and abdominal aortic aneurysm progression.BMC medical imaging · 2025Article
- High coffee consumption may increase aortic diameter and risk of abdominal aortic aneurysm in smokers.Scientific reports · 2025Article
- Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms.JACC. Basic to translational science · 2025Article
- Atractylenolide-I prevents abdominal aortic aneurysm formation through inhibiting inflammation.Frontiers in immunology · 2025Article
- Big data analytics and scRNA-seq in human aortic aneurysms and dissections: role of endothelial MerTK.Theranostics · 2025Article
- The first abdominal aortic aneurysm organoid model replicates complex microenvironment forTheranostics · 2025Article
- Article
- Prediction of the need for surgery in patients with unruptured abdominal aortic aneurysm based on SOFA score.PloS one · 2025Article
- Endograft-specific hemodynamics after endovascular aneurysm repair: a CFD analysis.Scientific reports · 2024Article
- The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese population.Scientific reports · 2024Article
- Highly sensitive magnetic particle imaging of abdominal aortic aneurysm NETosis with anti-Ly6G iron oxide nanoparticles.Cell death discovery · 2024Article
- Adenosine kinase inhibition protects mice from abdominal aortic aneurysm via epigenetic modulation of VSMC inflammation.Cardiovascular research · 2024Article
35 more citing papers are in PubMed but not listed here.
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Funding
Abstract
backgroundUltrasmall superparamagnetic particles of iron oxide (USPIO) detect cellular inflammation on magnetic resonance imaging (MRI). In patients with abdominal aortic aneurysm, we assessed whether USPIO-enhanced MRI can predict aneurysm growth rates and clinical outcomes.
methodsIn a prospective multicenter open-label cohort study, 342 patients with abdominal aortic aneurysm (diameter ≥40 mm) were classified by the presence of USPIO enhancement and were monitored with serial ultrasound and clinical follow-up for ≥2 years. The primary end point was the composite of aneurysm rupture or repair.
resultsParticipants (85% male, 73.1±7.2 years) had a baseline aneurysm diameter of 49.6±7.7 mm, and USPIO enhancement was identified in 146 (42.7%) participants, absent in 191 (55.8%), and indeterminant in 5 (1.5%). During follow-up (1005±280 days), 17 (5.0%) abdominal aortic aneurysm ruptures, 126 (36.8%) abdominal aortic aneurysm repairs, and 48 (14.0%) deaths occurred. Compared with those without uptake, patients with USPIO enhancement have increased rates of aneurysm expansion (3.1±2.5 versus 2.5±2.4 mm/year,
conclusionsUSPIO-enhanced MRI is a novel approach to the identification of aortic wall cellular inflammation in patients with abdominal aortic aneurysms and predicts the rate of aneurysm growth and clinical outcome. However, it does not provide independent prediction of aneurysm expansion or clinical outcomes in a model incorporating known clinical risk factors. CLINICAL
trial registrationURL: http://www.isrctn.com. Unique identifier: ISRCTN76413758.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.