Evidence map›Paper›PMID 28720666›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Inactivation of Receptor Tyrosine Kinases Reverts Aberrant DNA Methylation in Acute Myeloid Leukemia.

Na Shen, Fei Yan, Jiuxia Pang, Na Zhao, Naseema Gangat, Laichu Wu, Ann M Bode, Aref Al-Kali, Mark R Litzow, Shujun Liu

Registry-linked trialAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05042531 (Clinical Research for Azacitidine Combined With Low-dose Dasatinib in Maintenance Therapy of Acute Myeloid Leukemia), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05042531 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Clinical Research for Azacitidine Combined With Low-dose Dasatinib in Maintenance Therapy of Acute Myeloid Leukemia

TypeinterventionalSponsorLanZhou UniversityRan2021 to 2023Enrolled30ConditionsAcute Myeloid LeukemiaArmsAzacitidine, Dasatinib
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The RNA NCell death & disease · 2025
    Article
  4. Review
  5. Article
  6. The RNA NResearch square · 2024
    Article
  7. Review
  8. LncRNAiScience · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. An Assessment on Ethanol-Blended Gasoline/Diesel Fuels on Cancer Risk and Mortality.International journal of environmental research and public health · 2021
    Review
  15. Article
  16. [Advances in the mouse models of myeloid leukemia].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019
    Review
  17. Article
  18. Review
  19. A dynamic NCell research · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Na ShenThe Hormel Institute, University of Minnesota, Austin, Minnesota.
Fei YanThe Hormel Institute, University of Minnesota, Austin, Minnesota.
Jiuxia PangThe Hormel Institute, University of Minnesota, Austin, Minnesota.
Na ZhaoThe Hormel Institute, University of Minnesota, Austin, Minnesota.
Naseema GangatDivision of Hematology, Mayo Clinic, Rochester, Minnesota.
Laichu WuDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, Ohio.
Ann M BodeThe Hormel Institute, University of Minnesota, Austin, Minnesota.
Aref Al-KaliDivision of Hematology, Mayo Clinic, Rochester, Minnesota.
Mark R LitzowDivision of Hematology, Mayo Clinic, Rochester, Minnesota. sliu@hi.umn.edu Litzow.mark@mayo.edu.
Shujun LiuThe Hormel Institute, University of Minnesota, Austin, Minnesota. sliu@hi.umn.edu Litzow.mark@mayo.edu.
Hormel (United States) · USMayo Clinic · USThe Ohio State University · US

Funding

Targeting aberrant epigenetics by nanomedicineR01CA149623 · NCI · UNIVERSITY OF MINNESOTA · PI LIU, SHUJUN · 2010 to 2014
$1.8M
Bioactive compound modulation of epigenetic regulator Sp1/NFkB/miR network in AMLR21CA155915 · NCI · UNIVERSITY OF MINNESOTA · PI LIU, SHUJUN · 2011 to 2012
$365k
Targeting high fat diet-driven DNA hypermethylation for AML chemopreventionR03CA186176 · NCI · UNIVERSITY OF MINNESOTA · PI LIU, SHUJUN · 2016 to 2017
$155k
NCI NIH HHS R01 CA149623NCI NIH HHS R03 CA186176NCI NIH HHS R21 CA155915
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationAnimalsApoptosisCell Line, TumorCell ProliferationDisease Models, AnimalDNA (Cytosine-5-)-MethyltransferasesEnzyme ActivationFemaleGene Expression Regulation, NeoplasticHumansLeukemia, Myeloid, AcuteMicePromoter Regions, GeneticPyrimidinesReceptor Protein-Tyrosine KinasesDNA (Cytosine-5-)-MethyltransferasesnilotinibPyrimidinesReceptor Protein-Tyrosine KinasesSp1 Transcription Factor

Identifiers

PMID28720666
PMCPMC5641248
OpenAlexW2739363814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.