ReviewTrends in genetics : TIG2017
Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis.
Review in Trends in genetics : TIG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 172 citations in OpenAlex.
- Isomeric Bodily Situs in the Era of Universal Prenatal Detection: Highlighting Computed Tomographic Findings in Those with Complex Cardiovascular Malformations.Pediatric cardiology · 2026Article
- Germ layer-specific interaction of ion channels and transporters controls membrane potential and left-right patterning in Xenopus tropicalis.Communications biology · 2026Article
- Genetic drivers of congenital cardiac fibrosis.Communications biology · 2026Review
- Identification of novel biallelic mutations in CFAP53 associated with fetal situs inversus totalis and literature review.Journal of applied genetics · 2026Review
- Insights into the zebrafish left-right organizer's centrosomes and cilia via volume electron microscopy.Biology open · 2026Article
- Article
- Surgical Treatment of Meningioma with Situs Inversus Totalis Assisted by 3D Technology: A Case ReportCurrent medical imaging · 2026Article
- Dextrocardia with Situs Inversus Totalis in an Ethiopian Woman: A Case Report.Clinical medicine insights. Case reports · 2026Article
- Three-port laparoscopic cholecystectomy with common bile duct exploration in situs inverse totalis: a case report and literature review.Frontiers in surgery · 2026Article
- Organizer activity in the mouse embryo.Cells & development · 2025Review
- A conserved domain of Cfap298 governs left-right symmetry breaking in vertebrates.Journal of cell science · 2025Article
- Functionally Essential and Structurally Diverse: Insights into the zebrafish Left-Right Organizer's Cilia via Optogenetic IFT88 Perturbation and Volume Electron Microscopy.bioRxiv : the preprint server for biology · 2025Article
- Article
- Specific mitotic events drive left-right organizer development.Development (Cambridge, England) · 2025Article
- Spiral phyllotaxis predicts left-right asymmetric growth and style deflection in mirror-image flowers of Cyanella alba.Nature communications · 2025Article
- Cell recruitment and the origins of Anterior-Posterior asymmetries in the Drosophila wing.PloS one · 2025Article
- Breaking Left-Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia.Cells · 2024Review
- CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling.Developmental biology · 2024Article
- Canonical and Non-Canonical Wnt Signaling Generates Molecular and Cellular Asymmetries to Establish Embryonic Axes.Journal of developmental biology · 2024Review
- Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer.Development (Cambridge, England) · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrates exhibit striking left-right (L-R) asymmetries in the structure and position of the internal organs. Symmetry is broken by motile cilia-generated asymmetric fluid flow, resulting in a signaling cascade - the Nodal-Pitx2 pathway - being robustly established within mesodermal tissue on the left side only. This pathway impinges upon various organ primordia to instruct their side-specific development. Recently, progress has been made in understanding both the breaking of embryonic L-R symmetry and how the Nodal-Pitx2 pathway controls lateralized cell differentiation, migration, and other aspects of cell behavior, as well as tissue-level mechanisms, that drive asymmetries in organ formation. Proper execution of asymmetric organogenesis is critical to health, making furthering our understanding of L-R development an important concern.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.