ReviewSeminars in fetal & neonatal medicine2017
Perinatal and neonatal use of paracetamol for pain relief.
Review in Seminars in fetal & neonatal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia.The Cochrane database of systematic reviews · 2022Pooled it
- Gestational Paracetamol (Acetaminophen) Toxicity Induces Behavioral and Structural Brain Defects in Rats.Current issues in molecular biology · 2026Article
- Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective.International journal of molecular sciences · 2025Review
- Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review.Children (Basel, Switzerland) · 2024Review
- Postnatal acetaminophen exposure and neurodevelopmental outcomes at 18-21 months corrected gestational age in preterm infants <29 weeks gestation: a retrospective cohort study.Pediatric research · 2024Article
- How to translate neurocognitive and behavioural outcome data in animals exposed to paracetamol to the human perinatal setting?Archives of medical science : AMS · 2024Article
- Physiologically Based Pharmacokinetic Modeling in Neonates: Current Status and Future Perspectives.Pharmaceutics · 2023Review
- Cinnamon Oil Alleviates Acetaminophen-Induced Uterine Toxicity in Rats by Abrogation of Oxidative Stress, Apoptosis, and Inflammation.Plants (Basel, Switzerland) · 2023Article
- Dexmedetomidine: An Alternative to Pain Treatment in Neonatology.Children (Basel, Switzerland) · 2023Review
- Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- Interventions for the management of Pain and Sedation in Newborns undergoing Therapeutic hypothermia for hypoxic-ischemic encephalopathy (IPSNUT): protocol of a systematic review.Systematic reviews · 2022Article
- Antioxidants in Pregnancy: Do We Really Need More Trials?Antioxidants (Basel, Switzerland) · 2022Review
- An assessment of dexmedetomidine as an opioid-sparing agent after neonatal open thoracic and abdominal operations.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Association between paracetamol use during pregnancy and perinatal outcomes: Prospective NISAMI cohort.PloS one · 2022Article
- Modelling Tools to Characterize Acetaminophen Pharmacokinetics in the Pregnant Population.Pharmaceutics · 2021Review
- Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?The Journal of pediatrics · 2021Review
- The developing murine lung is susceptible to acetaminophen toxicity.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Mechanistic Coupling of a NovelFrontiers in pediatrics · 2021Article
- Integration of Placental Transfer in a Fetal-Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus.Clinical pharmacokinetics · 2020Article
- Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women.Clinical pharmacokinetics · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paracetamol (acetaminophen) is the most widely used drug to treat pain or fever in pregnant women or neonates, but its pharmacokinetics (PK) and pharmacodynamics (PD) warrant a focused analysis. During pregnancy, there is an important increase in paracetamol clearance. Consequently, it is reasonable to anticipate that the analgesic effect of paracetamol will decrease faster, whereas higher doses may result in even higher oxidative toxic metabolites. Therefore, most peripartal PD data relate to multimodal analgesia strategies. In neonates, weight/size is the most relevant covariate of paracetamol PK. This resulted in proposed dosing regimens containing higher doses than currently prescribed in the label for term neonates. Using adequate dosing, paracetamol is a poor procedural analgesic, is effective for mild-to-moderate pain, and has morphine-sparing effects. Short-term safety has been well documented, and there is active research investigating the potential association between paracetamol exposure and atopy, fertility, and neurobehavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.