ArticleInternational journal of hygiene and environmental health2017
Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California.
Article in International journal of hygiene and environmental health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between Outdoor Air Pollution and Childhood Leukemia: A Systematic Review and Dose-Response Meta-Analysis.Environmental health perspectives · 2019Pooled it
- Integrating the physical environment into Alzheimer's disease and Alzheimer's disease related dementias research: A Gateway Exposome Coordinating Center (GECC) agenda on gaps and priorities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Causes of Childhood Cancer: A Literature Review (2014-2021)-Part 3: Environmental and Occupational Factors.Cancers · 2025Review
- Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988-2015).Environmental health : a global access science source · 2025Article
- Maternal Exposure to Heavy Metals From Industrial Sources During Pregnancy and Childhood Cancer Risk in California.Journal of occupational and environmental medicine · 2024Article
- Maternal residential exposure to solvents from industrial sources during pregnancy and childhood cancer risk in California.International journal of hygiene and environmental health · 2024Article
- Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade.International journal of molecular sciences · 2024Article
- Dichloromethane-Induced Poisoning from Acrylic Paint Cleaner - Shenzhen City, Guangdong Province, China, 2023.China CDC weekly · 2023Article
- Parental occupation and childhood germ cell tumors: a case-control study in Denmark, 1968-2016.Cancer causes & control : CCC · 2021Article
- Air pollution exposure at the residence and risk of childhood cancers in Denmark: A nationwide register-based case-control study.EClinicalMedicine · 2020Article
- Prenatal pesticide exposure and childhood leukemia - A California statewide case-control study.International journal of hygiene and environmental health · 2020Article
- Biological monitoring of occupational exposure to dichloromethane by means of urinalysis for un-metabolized dichloromethane.Industrial health · 2020Article
- Methodological approaches to the study of cancer risk in the vicinity of pollution sources: the experience of a population-based case-control study of childhood cancer.International journal of health geographics · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe incidence of childhood cancers has been increasing and environmental exposure to air toxics has been suggested as a possible risk factor. This study aims to explore ambient exposure to dichloromethane (methylene chloride).
methodsWe frequency matched by birth year approximately 20 cancer-free controls identified from birth records to all childhood cancers ages 0-5 in the California Cancer Registry diagnosed from 1988 to 2012; i.e. 13,636 cases and a total of 270,673 controls. Information on industrial releases of dichloromethane within 3km of birth addresses was retrieved from mandatory industry reports to the EPA's Toxics Release Inventory (TRI). We derived exposure to dichloromethane within close vicinity of birth residences using several modeling techniques including unconditional logistic regression models with multiple buffer distances, inverse distance weighting, and quadratic decay models.
resultsWe observed elevated risks for germ cell tumors [Odds Ratio (OR): 1.52, 95% Confidence Interval (CI) 1.11, 2.08], particularly teratomas (OR: 2.08, 95% CI 1.38-3.13), and possible increased risk for acute myeloid leukemias (AML) (OR: 1.64, 95% CI 1.15-2.32 in the quadratic decay model). Risk estimates were similar in magnitude whether releases occurred in pregnancy or the child's first year of life.
conclusionOur findings suggest that exposure to industrial dichloromethane releases may be a risk factor for childhood germ cell tumors, teratomas, and possibly AML.
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