ArticleAmerican journal of surgery2017
Body mass index mediates the prognostic significance of circulating tumor cells in inflammatory breast cancer.
Article in American journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Trial
- Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status.Cellular and molecular bioengineering · 2023Article
- Circulating tumour cell enumeration does not correlate with Miller-Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy.Breast cancer research and treatment · 2020Article
- Unequal Protective Effects of Parental Educational Attainment on the Body Mass Index of Black and White Youth.International journal of environmental research and public health · 2019Article
- Article
- Presence of circulating tumor cells is associated with metabolic-related variables in postoperative patients with early-stage breast cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObesity (BMI≥30) may be an etiologic and prognostic factor in inflammatory breast cancer (IBC). We examined the relationship between BMI, pathologic complete response (pCR), and circulating-tumor-cell (CTC) levels in IBC.
methodsCohort included IBC patients diagnosed 2005-2015 who had neoadjuvant chemotherapy during a prospective trial on CTCs and pathologic review describing pCR. Chi-square, logistic regression, and Cox proportional hazards models were used to identify clinicopathologic associations with event-free survival (EFS).
resultsOf 73 patients, 61 (84%) had CTC values, 22 (30%) achieved a pCR, and 39 (53%) were obese. There was no difference between obese and non-obese patients for pCR rates (31% vs. 29%, p = 0.90) or presence of CTCs (23% vs. 26%, p = 0.80). Among non-obese patients, CTCs were associated with worse EFS (HR 11.69, p < 0.01), but among obese patients, there was no difference in EFS between those with and without CTCs.
conclusionsBMI mediates CTCs' prognostic significance in IBC.
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Registered trials
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