Evidence map›Paper›PMID 28720216›Full record

ArticleAmerican journal of surgery2017

The effects of red cell transfusion donor age on nosocomial infection among trauma patients.

Tyler J Loftus, Ryan M Thomas, Travis W Murphy, Linda L Nguyen, Frederick A Moore, Scott C Brakenridge, Philip A Efron, Alicia M Mohr

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tyler J LoftusUniversity of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Tyler.Loftus@surgery.ufl.edu.
Ryan M ThomasMalcom Randall Veterans Affairs Medical Center Department of Surgery, Gainesville, FL, USA. Electronic address: Ryan.Thomas@surgery.ufl.edu.
Travis W MurphyUniversity of Florida Health Department of Emergency Medicine, Gainesville, FL, USA. Electronic address: Travis.Murphy@surgery.ufl.edu.
Linda L NguyenUniversity of Florida Health College of Medicine, Gainesville, FL, USA. Electronic address: Linda.Nguyen@ufl.edu.
Frederick A MooreUniversity of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Frederick.Moore@surgery.ufl.edu.
Scott C BrakenridgeUniversity of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Scott.Brakenridge@surgery.ufl.edu.
Philip A EfronUniversity of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Philip.Efron@surgery.ufl.edu.
Alicia M MohrUniversity of Florida Health Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, FL, USA. Electronic address: Alicia.Mohr@surgery.ufl.edu.
University of Florida Health · USMalcom Randall VA Medical Center · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7M
Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
Chronic Stress and Anemia Recovery following Major TraumaR01GM105893 · NIGMS · UNIVERSITY OF FLORIDA · PI MOHR, ALICIA M · 2013 to 2021
$3.5M
Hematopoietic Stem Cell Dysfunction in the Elderly after Severe InjuryR01GM113945 · NIGMS · UNIVERSITY OF FLORIDA · PI EFRON, PHILIP A · 2015 to 2019
$1.6M
NCATS NIH HHS UL1 TR001427NIA NIH HHS P30 AG028740NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM105893NIGMS NIH HHS R01 GM113945NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

backgroundWe hypothesized that packed red blood cell (PRBC) transfusions from older donors would be associated with fewer nosocomial infections among trauma patients.

methodsWe performed a four-year retrospective analysis of 264 consecutive adult trauma patients who received ≥1 PRBC transfusion during admission. The capacity of donor age to predict nosocomial infection was assessed by logistic regression.

resultsThirty-three percent of all patients developed a nosocomial infection. Donor age was significantly higher among patients with nosocomial infection (40.3 vs. 37.6 years, p = 0.035), and the incidence of infection was directly proportional to donor age. The association between donor age and infection was strongest among recipients age ≥60 years, and was significant on multivariate regression for this cohort (OR 1.07 (95% CI 1.01-1.13), p = 0.024).

conclusionsAmong trauma patients receiving PRBC transfusions, blood from older donors may be associated with increased risk for nosocomial infection.

Indexed as

Erythrocyte TransfusionAge FactorsCross InfectionFemaleHumansIncidenceInjury Severity ScoreMaleMiddle AgedRetrospective StudiesRisk FactorsWounds and InjuriesAgeDonorNosocomial infectionRecipientTransfusionTrauma

Identifiers

PMID28720216
PMCPMC5603393
OpenAlexW2735886197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.