Trial reportTrials2017
The effectiveness of daily SMS reminders in pharmaceutical care of older adults on improving patients' adherence to antihypertensive medication (SPPA): study protocol for a randomized controlled trial.
Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03105687 (A Multicenter, Assessor-blinded, Controlled, Randomised, Parallel Group, Superiority, Pragmatic Trial Assessing the Effectiveness of Daily SMS-reminders in Pharmaceutical Care of Older Adults With Hypertension on Improving Patients' Adherence to Blood Pressure-lowering Medication), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter, Assessor-blinded, Controlled, Randomised, Parallel Group, Superiority, Pragmatic Trial Assessing the Effectiveness of Daily SMS-reminders in Pharmaceutical Care of Older Adults With Hypertension on Improving Patients' Adherence to Blood Pressure-lowering Medication
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Mobile phone text messaging for medication adherence in secondary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2024Pooled it
- Mobile phone-based interventions for improving adherence to medication prescribed for the primary prevention of cardiovascular disease in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Interventions for improving medication-taking ability and adherence in older adults prescribed multiple medications.The Cochrane database of systematic reviews · 2020Pooled it
- How Behavior Change Strategies are Used to Design Digital Interventions to Improve Medication Adherence and Blood Pressure Among Patients With Hypertension: Systematic Review.Journal of medical Internet research · 2020Pooled it
- Incorporating Behavioral Science in Medication Adherence Communication: A Randomized Clinical Trial.JAMA network open · 2025Trial
- The role of training and medication reminder wristwatch in adherence to treatment in geriatric patients diagnosed with hypertension: A randomized controlled trial.Geriatrics & gerontology international · 2024Trial
- Yoga therapy to reduce fatigue in cancer: effects of reminder e-mails and long-term efficacy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Trial
- Efficacy of Text Messaging and Personal Consultation by Pharmacy Students Among Adults With Hypertension: Randomized Controlled Trial.Journal of medical Internet research · 2020Trial
- Key Elements and Theoretical Foundations for the Design and Delivery of Text Messages to Boost Medication Adherence in Patients With Diabetes, Hypertension, and Hyperlipidemia: Scoping Review.Journal of medical Internet research · 2025Article
- Exploring the Role of the Pharmacist in the Prevention and Management of Hypertensive Disorders in Pregnancy in Ashanti Region, Ghana.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Article
- Patient Pill Organization Strategies and Adherence Measured in a Cross-Sectional Study of Hypertension.Patient preference and adherence · 2023Article
- Clinical Analysis on the Effects of Tandospirone Citrate Assisted by Drawing Therapy on Medication Compliance and Sleep Quality in Patients with Anxiety Disorders.Emergency medicine international · 2022Article
- The use of an electronic medication organizer device with alarm to improve medication adherence of older adults with hypertension.Einstein (Sao Paulo, Brazil) · 2021Article
- Patients Satisfaction with Pharmaceutical Care and Associated Factors in the Southwestern Ethiopia.Patient preference and adherence · 2021Article
- Yoga intervention and reminder e-mails for reducing cancer-related fatigue - a study protocol of a randomized controlled trial.BMC psychology · 2019Article
- Effects of Customized Long-Message Service and Phone-Based Health-Coaching on Elderly People with Hypertension.Iranian journal of public health · 2019Article
- The impact of short message services and personal consultation by pharmacy students on medication adherence and blood pressure control: study protocol for a cluster randomized trial.Patient preference and adherence · 2019Article
- Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic?BMC medicine · 2018Article
- Post-discharge evaluation of medication adherence and knowledge of hypertension among hypertensive stroke patients in northwestern China.Patient preference and adherence · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite a variety of efficient and cost-effective antihypertensive medication, hypertension remains a serious health and economic burden. High consumption of cardiovascular drugs in the Slovak Republic does result neither in better hypertension control nor in significant decrease in cardiovascular mortality. At the same time, Slovakia has alarmingly low patients' adherence to medication intake. Studies have shown the efficiency of short messaging service (SMS) reminders to improve patients' adherence and health outcomes at low costs. Since SMS is popular among Slovaks, this approach may be feasible also in Slovakia. The primary objective is to assess if daily SMS reminders of antihypertensive medication intake provided by pharmacists in addition to the standard pharmaceutical care increase the proportion of adherent older hypertensive ambulatory patients.
methodsThe SPPA trial is a pragmatic randomized parallel group (1:1) trial in 300 older hypertensive patients carried out in community pharmacies in Slovakia. Trial pharmacies will be selected from all main regions of Slovakia. Trial intervention comprises daily personalized SMS reminders of medication intake embedded into usual pharmaceutical practice. The primary outcome is a combined adherence endpoint consisting of subjective self-reported medication adherence via the eight-item Morisky Medication Adherence Scale (MMAS-8) and objective pill count rate. Secondary outcomes include: change in the MMAS-8; comparison of adherence rates using pill count; change in systolic blood pressure; and patient satisfaction. Also, direct treatment costs will be evaluated and a cost-effectiveness analysis will be carried out. DISCUSSION: The SPPA trial engages community pharmacists and mobile health (mHealth) technologies via evidence-based pharmaceutical care to efficiently and cost-effectively addresses current main healthcare challenges: high prevalence of hypertension; overconsumption of cardiovascular medicines; low adherence to medication treatment; and resulting uncontrolled blood pressure. The results may identify new possibilities and capacities in healthcare with low additional costs and high value to patients.
trial registrationClinicalTrials.gov, NCT03105687 . Registered on 07 March 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.