ArticleAnnals of the American Thoracic Society2017
Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension.
Article in Annals of the American Thoracic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Incidence of primary graft dysfunction and its associated risk factors after lung transplantation: a systematic review and meta-analysis.Surgery today · 2025Pooled it
- Alveolus-on-a-chip: A Novel Tool for Modeling Lung Transplant Cold Storage Ischemia/Reperfusion Injury.Transplantation · 2026Article
- Right Ventricular Stroke Work Index and Its Prognostic Value in a Lung Transplant Population With Group 3 Pulmonary Hypertension.Journal of transplantation · 2026Article
- Prediction of massive intraoperative blood transfusion requirement in lung transplantation.Frontiers in medicine · 2026Article
- Lung Ischemia-Reperfusion Injury in Lung Transplant Surgery: Where Do We Stand?Antioxidants (Basel, Switzerland) · 2025Review
- Extended Use of Central Veno-Arterial Extracorporeal Membrane Oxygenation in Lung Transplantation for Patients with Pulmonary Arterial Hypertension.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- A nationwide survey on current practices in anesthesia management for lung transplantation in China.Scientific reports · 2025Article
- Post lung-transplant predictive value of thermodilution vs estimated Fick cardiac output measurement.JHLT open · 2025Article
- Approach to Lung Transplantation in Pulmonary Arterial Hypertension: A Delphi Consensus on Behalf of the Transplant Task Force of the Pulmonary Vascular Research Institute.Pulmonary circulation · 2025Article
- The Potential of Pulmonary Vasodilators as a Bridging Therapy for Lung Transplantation: Two Cases of Interstitial Pneumonia With Pulmonary Hypertension During the Waiting Period for Lung Transplantation.Respirology case reports · 2025Article
- Combined pulmonary fibrosis and emphysema and lung transplantation: current evidence and future directions.Journal of thoracic disease · 2024Article
- Transplantation, bridging, and support technologies in pulmonary hypertension.The European respiratory journal · 2024Review
- Contrasting predictors of severe primary graft dysfunction following transplant for chronic and acute respiratory failure.Journal of thoracic disease · 2024Article
- Analysis of Primary Graft Dysfunction (PGD) Risk Factors in Lung Transplantation (LuTx) Patients.Clinics and practice · 2024Article
- Impact of Pre-Transplant Left Ventricular Diastolic Pressure on Primary Graft Dysfunction after Lung Transplantation: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- A novel nomogram for predicting prolonged mechanical ventilation in lung transplantation patients using extracorporeal membrane oxygenation.Scientific reports · 2024Article
- Predictors of early mortality after lung transplantation for idiopathic pulmonary arterial hypertension.Pulmonary circulation · 2024Article
- Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.American journal of respiratory and critical care medicine · 2024Article
- Postreperfusion Pulmonary Artery Pressure Indicates Primary Graft Dysfunction After Lung Transplant.The Annals of thoracic surgery · 2024Article
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Authors and funding
23 authors at 13 institutions in 2 countries.
Funding
Abstract
rationalePulmonary hypertension from pulmonary arterial hypertension or parenchymal lung disease is associated with an increased risk for primary graft dysfunction after lung transplantation.
objectiveWe evaluated the clinical determinants of severe primary graft dysfunction in pulmonary hypertension and developed and validated a prognostic model.
methodsWe conducted a retrospective cohort study of patients in the multicenter Lung Transplant Outcomes Group with pulmonary hypertension at transplant listing. Severe primary graft dysfunction was defined as Pa
resultsIn the explanatory model of 826 patients with pulmonary hypertension, donor tobacco smoke exposure, higher recipient body mass index, female sex, listing mean pulmonary artery pressure, right atrial pressure and creatinine at transplant, cardiopulmonary bypass use, transfusion volume, and reperfusion fraction of inspired oxygen were associated with primary graft dysfunction. Donor obesity was associated with a lower risk for primary graft dysfunction. Using a 20% threshold for elevated risk, the prognostic model had good negative predictive value in both derivation and validation cohorts (89.1% [95% confidence interval, 85.3-92.8] and 83.3% [95% confidence interval, 78.5-88.2], respectively), but low positive predictive value.
conclusionsSeveral recipient, donor, and operative characteristics were associated with severe primary graft dysfunction in patients with pulmonary hypertension, including several risk factors not identified in the overall transplant population. A prognostic model with donor and recipient clinical risk factors alone had low positive predictive value, but high negative predictive value, to rule out high risk for primary graft dysfunction.
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