Evidence map›Paper›PMID 28719693›Full record

Trial reportJAMA2017

Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children.

Mary Aglipay, Catherine S Birken, Patricia C Parkin, Mark B Loeb, Kevin Thorpe, Yang Chen, Andreas Laupacis, Muhammad Mamdani, Colin Macarthur, Jeffrey S Hoch and 3 more

Registry-linked trialOpen access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JAMA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01419262 (DO IT Trial), which is not on this map. Cited by 76 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 19 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01419262 phase3completednot on this map

DO IT Trial: Vitamin D Outcomes and Interventions In Toddlers

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2011 to 2015Enrolled703ConditionsRespiratory Tract Infections, Asthma, AvitaminosisArmsVitamin D - Cholecalciferol 400 IU, Vitamin D3 - Cholecalciferol 2000 IU
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 19 syntheses or guidelines pooled it, 156 citations in OpenAlex.

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  8. Vitamin D for the management of asthma.The Cochrane database of systematic reviews · 2023
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  15. Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis.QJM : monthly journal of the Association of Physicians · 2021
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Mary AglipayDepartment of Pediatrics, St Michael's Hospital, Pediatric Research, Toronto, Ontario, Canada.
Catherine S BirkenPediatric Outcomes Research Team, Division of Pediatric Medicine, Department of Pediatrics, the Hospital for Sick Children, Toronto, Ontario, Canada3Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada4Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada5Child Health Evaluative Sciences, Sick Kids Research Institute, Toronto, Ontario, Canada.
Patricia C ParkinPediatric Outcomes Research Team, Division of Pediatric Medicine, Department of Pediatrics, the Hospital for Sick Children, Toronto, Ontario, Canada3Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada4Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada5Child Health Evaluative Sciences, Sick Kids Research Institute, Toronto, Ontario, Canada.
Mark B LoebDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada7Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Kevin ThorpeThe La Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada9Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Yang ChenThe La Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Andreas LaupacisThe La Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada10Institute for Clinical Evaluative Sciences, Toronto, Canada11Faculty of Medicine, University of Toronto, Toronto, Canada.
Muhammad MamdaniThe La Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Colin MacarthurPediatric Outcomes Research Team, Division of Pediatric Medicine, Department of Pediatrics, the Hospital for Sick Children, Toronto, Ontario, Canada3Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada4Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada5Child Health Evaluative Sciences, Sick Kids Research Institute, Toronto, Ontario, Canada.
Jeffrey S HochInstitute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada8The La Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada12Department of Public Health Sciences, University of California, Davis, California.
Tony MazzulliDepartment of Microbiology, Mount Sinai Hospital, Toronto, Ontario, Canada14Department of Laboratory Medicine & Pathobiology, University of Toronto, Ontario, Canada.
Jonathon L MaguireDepartment of Pediatrics, St Michael's Hospital, Pediatric Research, Toronto, Ontario, Canada2Pediatric Outcomes Research Team, Division of Pediatric Medicine, Department of Pediatrics, the Hospital for Sick Children, Toronto, Ontario, Canada3Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada4Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada8The La Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
TARGet Kids! Collaboration
University of Toronto · CASt. Michael's Hospital · CAHospital for Sick Children · CAInstitute for Clinical Evaluative Sciences · CAMcMaster University · CAMount Sinai Hospital · CAPublic Health Ontario · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceEpidemiological studies support a link between low 25-hydroxyvitamin D levels and a higher risk of viral upper respiratory tract infections. However, whether winter supplementation of vitamin D reduces the risk among children is unknown.

objectiveTo determine whether high-dose vs standard-dose vitamin D supplementation reduces the incidence of wintertime upper respiratory tract infections in young children. DESIGN, SETTING, AND

participantsA randomized clinical trial was conducted during the winter months between September 13, 2011, and June 30, 2015, among children aged 1 through 5 years enrolled in TARGet Kids!, a multisite primary care practice-based research network in Toronto, Ontario, Canada.

interventionsThree hundred forty-nine participants were randomized to receive 2000 IU/d of vitamin D oral supplementation (high-dose group) vs 354 participants who were randomized to receive 400 IU/d (standard-dose group) for a minimum of 4 months between September and May.

main outcome measuresThe primary outcome was the number of laboratory-confirmed viral upper respiratory tract infections based on parent-collected nasal swabs over the winter months. Secondary outcomes included the number of influenza infections, noninfluenza infections, parent-reported upper respiratory tract illnesses, time to first upper respiratory tract infection, and serum 25-hydroxyvitamin D levels at study termination.

resultsAmong 703 participants who were randomized (mean age, 2.7 years, 57.7% boys), 699 (99.4%) completed the trial. The mean number of laboratory-confirmed upper respiratory tract infections per child was 1.05 (95% CI, 0.91-1.19) for the high-dose group and 1.03 (95% CI, 0.90-1.16) for the standard-dose group, for a between-group difference of 0.02 (95% CI, -0.17 to 0.21) per child. There was no statistically significant difference in number of laboratory-confirmed infections between groups (incidence rate ratio [RR], 0.97; 95% CI, 0.80-1.16). There was also no significant difference in the median time to the first laboratory-confirmed infection: 3.95 months (95% CI, 3.02-5.95 months) for the high-dose group vs 3.29 months (95% CI, 2.66-4.14 months) for the standard-dose group, or number of parent-reported upper respiratory tract illnesses between groups (625 for high-dose vs 600 for standard-dose groups, incidence RR, 1.01; 95% CI, 0.88-1.16). At study termination, serum 25-hydroxyvitamin D levels were 48.7 ng/mL (95% CI, 46.9-50.5 ng/mL) in the high-dose group and 36.8 ng/mL (95% CI, 35.4-38.2 ng/mL) in the standard-dose group. CONCLUSIONS AND RELEVANCE: Among healthy children aged 1 to 5 years, daily administration of 2000 IU compared with 400 IU of vitamin D supplementation did not reduce overall wintertime upper respiratory tract infections. These findings do not support the routine use of high-dose vitamin D supplementation in children for the prevention of viral upper respiratory tract infections.

trial registrationclinicaltrials.gov Identifier: NCT01419262.

Indexed as

Dietary SupplementsAdministration, OralChild, PreschoolCommon ColdDose-Response Relationship, DrugFemaleHumansIncidenceInfantInfluenza, HumanMaleNoseRespiratory Tract InfectionsVirus DiseasesVitamin DVitamins25-hydroxyvitamin DVitamin DVitamins

Identifiers

PMID28719693
PMCPMC5817430
OpenAlexW2738344725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.