Evidence map›Paper›PMID 28719669›Full record

Trial reportPloS one2017

A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial.

Kirsten E Bell, Tim Snijders, Michael Zulyniak, Dinesh Kumbhare, Gianni Parise, Adrian Chabowski, Stuart M Phillips

Erratum issued 2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02281331 nacompletednot on this map

Evaluation of the Effects of a Combined Resistance and High-intensity Interval Exercise Training Program, Along With Nutritional Supplementation, on Strength and Physical Function in Older Men

TypeinterventionalSponsorMcMaster UniversityRan2014 to 2018Enrolled50ConditionsAgingArmsSupplement
NCT03536871 nacompletednot on this mapstarted 2018, after this paper: background citation

Exercise and Nutritional Supplementation for Aging and Sedentary Lifestyles

TypeinterventionalSponsorMcMaster UniversityRan2018 to 2019Enrolled45ConditionsSarcopenia, Healthy Elderly, Healthy YoungArmsmulti-nutrient supplement, Exercise
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kirsten E BellExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
Tim SnijdersExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
Michael ZulyniakDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Dinesh KumbhareDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Gianni PariseExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
Adrian ChabowskiDepartment of Physiology, Medical University of Bialystok, Bialystok, Poland.
Stuart M PhillipsExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0002-1956-4098

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 ± 1 years [mean ± SEM]; BMI: 28.5 ± 1.5 kg/m2) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, 400 mg calcium, and 1500 mg n-3 PUFA with 700 mg as eicosapentanoic acid and 445 mg as docosahexanoic acid); or a control (n = 24; CON; 22 g of maltodextrin). The study had two phases. Phase 1 was 6 weeks of SUPP or CON alone. Phase 2 was a 12 week continuation of the SUPP/CON but in combination with exercise: SUPP + EX or CON + EX. Isotonic strength (one repetition maximum [1RM]) and lean body mass (LBM) were the primary outcomes. In Phase 1 only the SUPP group gained strength (Σ1RM, SUPP: +14 ± 4 kg, CON: +3 ± 2 kg, P < 0.001) and lean mass (LBM, +1.2 ± 0.3 kg, CON: -0.1 ± 0.2 kg, P < 0.001). Although both groups gained strength during Phase 2, upon completion of the study upper body strength was greater in the SUPP group compared to the CON group (Σ upper body 1RM: 119 ± 4 vs. 109 ± 5 kg, P = 0.039). We conclude that twice daily consumption of a multi-ingredient nutritional supplement increased muscle strength and lean mass in older men. Increases in strength were enhanced further with exercise training.

trial registrationClinicalTrials.gov NCT02281331.

Indexed as

Dietary SupplementsHealthy VolunteersAgedBody CompositionExerciseFastingFemaleHumansLipidsMaleMuscle StrengthWhey ProteinsLipidsWhey Proteins

Identifiers

PMID28719669
PMCPMC5515445

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.