Evidence map›Paper›PMID 28719609›Full record

Trial reportPloS one2017

Renal function following xenon anesthesia for partial nephrectomy-An explorative analysis of a randomized controlled study.

Ana Stevanovic, Patrick Schaefer, Mark Coburn, Rolf Rossaint, Christian Stoppe, Peter Boor, David Pfister, Axel Heidenreich, Hildegard Christ, Martin Hellmich and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01839084 (Impact of Xenon-anesthesia on the Renal Function After Partial Nephrectomy - PaNeX), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01839084 phase3completednot on this map

Impact of Xenon-anesthesia on the Renal Function After Partial Nephrectomy - PaNeX: Partial Nephrectomy Under Xenon:a Pilot Study

TypeinterventionalSponsorRWTH Aachen UniversityRan2013 to 2016Enrolled46ConditionsRenal Function After Partial NephrectomyArmsXenon, Isoflurane
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Effect of Inhalation Anesthetics on Tumor Metastasis.Technology in cancer research & treatment
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ana StevanovicDepartment of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0002-7433-8675
Patrick SchaeferMedical Faculty, University of RWTH Aachen, Aachen, Germany.
Mark CoburnDepartment of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany.
Rolf RossaintDepartment of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany.
Christian StoppeDepartment of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany.
Peter BoorInstitute of Pathology, University Hospital of RWTH Aachen, Aachen, Germany.
David PfisterDepartment of Urology, University Hospital of Cologne, Cologne, Germany.
Axel HeidenreichDepartment of Urology, University Hospital of Cologne, Cologne, Germany.
Hildegard ChristInstitute of Medical Statistics, Informatics and Epidemiology (IMSIE), University of Cologne, Cologne, Germany.
Martin HellmichInstitute of Medical Statistics, Informatics and Epidemiology (IMSIE), University of Cologne, Cologne, Germany.
Astrid V FahlenkampDepartment of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany.
RWTH Aachen University · DEUniversity Hospital Cologne · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerioperative preservation of renal function has a significant impact on morbidity and mortality in kidney surgery. Nephroprotective effects of the anesthetic xenon on ischemia-reperfusion injury were found in several experimental studies.

objectiveWe aimed to explore whether xenon anesthesia can reduce renal damage in humans undergoing partial nephrectomy and to gather pilot data of possible nephroprotection in these patients.

designA prospective randomized, single-blinded, controlled study.

settingSingle-center, University Hospital of Aachen, Germany between July 2013-October 2015. PATIENTS: Forty-six patients with regular renal function undergoing partial nephrectomy.

interventionsPatients were randomly assigned to receive xenon- (n = 23) or isoflurane (n = 23) anesthesia.

main outcome measuresPrimary outcome was the maximum postoperative glomerular filtration rate (GFR) decline within seven days after surgery. Secondary outcomes included intraoperative and tumor-related data, assessment of further kidney injury markers, adverse events and optional determination of renal function after 3-6 months.

resultsUnexpected radical nephrectomy was performed in 5 patients, thus they were excluded from the per-protocol analysis, but included in the intention-to-treat analysis. The maximum postoperative GFR decline was attenuated by 45% in the xenon-group (10.9 ml min-1 1.73 cm-2 versus 19.7 ml min-1 1.73 cm-2 in the isoflurane group), but without significance (P = 0.084). Occurrence of adverse events was reduced (P = 0.003) in the xenon group. Renal function was similar among the groups after 3-6 months.

conclusionXenon anesthesia was feasible and safe in patients undergoing partial nephrectomy with regard to postoperative renal function. We found no significant effect on early renal function but less adverse events in the xenon group. Larger randomized controlled studies in more heterogeneous collectives are required, to confirm or refute the possible clinical benefit on renal function by xenon.

trial registrationClinicalTrials.gov NCT01839084 and EudraCT 2012-005698-30.

Indexed as

Anesthetics, InhalationFemaleHumansKidneyKidney NeoplasmsMaleMiddle AgedNephrectomyPerioperative PeriodTime FactorsXenonAnesthetics, InhalationXenon

Identifiers

PMID28719609
PMCPMC5515428
OpenAlexW2739174018

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.