ArticleThe pharmacogenomics journal2018
Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology.
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In one paragraph
Article in The pharmacogenomics journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review.PharmacogenomicsPooled it
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
74 authors at 20 institutions in 7 countries.
A A SeyerleDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
C M SitlaniDepartment of Medicine, University of Washington, Seattle, WA, USA.
R NoordamDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
S M GogartenDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
J LiDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
X LiInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
D S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
F SunDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
M A LaaksonenDepartment of Health, THL-National Institute for Health and Welfare, Helsinki, Finland.
A IsaacsDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
K KristianssonDepartment of Health, THL-National Institute for Health and Welfare, Helsinki, Finland.
H M HighlandDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
J D StewartDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
T B HarrisLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
S TrompetDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
J C BisDepartment of Medicine, University of Washington, Seattle, WA, USA.
G M PelosoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
J A BrodyDepartment of Medicine, University of Washington, Seattle, WA, USA.
L BroerDepartment of Internal Medicine, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
E L BuschChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Q DuanDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
A M StilpDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
C J O'DonnellDepartment of Medicine, Harvard University, Boston, MA, USA.
P W MacfarlaneInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
J S FloydDepartment of Medicine, University of Washington, Seattle, WA, USA.
J A KorsDepartment of Medical Informatics, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
H J LinInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
R Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
T SoferDepartment of Medicine, University of Washington, Seattle, WA, USA.
R Méndez-GiráldezDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
S R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
S R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
A HofmanDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
I FordRobertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
Y LiDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
L J LaunerLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
K PorthanDivision of Cardiology, Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland.
C Newton-ChehInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
M D NapierDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
K F KerrDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
A P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
K M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
J RoachResearch Computing Center, University of North Carolina, Chapel Hill, NC, USA.
B M BuckleyDepartment of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.
E Z SolimanEpidemiology Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston-Salem, NC, USA.
R de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
N SotoodehniaDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
A G UitterlindenDepartment of Internal Medicine, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
K E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
C R LeeDivision of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.
V GudnasonIcelandic Heart Association, Kopavogur, Iceland.
T StürmerDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
F R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
K D TaylorInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
K L WigginsDepartment of Medicine, University of Washington, Seattle, WA, USA.
J G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Y-Di ChenInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
R C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
K WilhelmsenDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
L A CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
V SalomaaDepartment of Health, THL-National Institute for Health and Welfare, Helsinki, Finland.
C van DuijnDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
J W JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Y LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC, USA.
D O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
L A LangeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
R S VasanNational Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.
A V SmithIcelandic Heart Association, Kopavogur, Iceland.
B H StrickerDepartment of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands.
C C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
J I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
E A WhitselDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
B M PsatyDepartment of Medicine, University of Washington, Seattle, WA, USA.
C L AveryDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USUniversity of Washington · USErasmus MC · NLLeiden University Medical Center · NLBoston University · USFinnish Institute for Health and Welfare · FICalifornia Pacific Medical Center · USHarbor–UCLA Medical Center · USNational Institute on Aging · USThe Lundquist Institute · USUniversity of Glasgow · GBUniversity of Iceland · ISWake Forest University · USAlbert Einstein College of Medicine · USBroad Institute · USDutch Health Care Inspectorate · NLFramingham Heart Study · USFred Hutch Cancer Center · USHarvard University · USHelsinki University Hospital · FI
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MTracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MTraining Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3MUCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MCardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0MNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCI NIH HHS T32 CA009001NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1 RR033176NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG005152NHLBI NIH HHS HHSN268200782096CNHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K23 HL080025NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R00 HL098458NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111089NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL120393NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL007779NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS HHSN271201100004CNIA NIH HHS HHSN271201200022CNIA NIH HHS N01 AG012100NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG032098NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES017794NIGMS NIH HHS U54 GM115428WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common single-nucleotide polymorphisms (SNPs) modified the association between thiazide use and QT or its component parts (QRS interval, JT interval) by performing ancestry-specific, trans-ethnic and cross-phenotype genome-wide analyses of European (66%), African American (15%) and Hispanic (19%) populations (N=78 199), leveraging longitudinal data, incorporating corrected standard errors to account for underestimation of interaction estimate variances and evaluating evidence for pathway enrichment. Although no loci achieved genome-wide significance (P<5 × 10
Indexed as
AdultAgedAged, 80 and overAgingCohort StudiesElectrocardiographyEthnicityFemaleGenomicsHeart RateHumansLongitudinal StudiesMaleMiddle AgedPharmacogeneticsPolymorphism, Single NucleotideSodium Chloride Symporter Inhibitors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.