Trial reportThe American journal of gastroenterology2018
Prophylactic Therapy of Cyclic Vomiting Syndrome in Children: Comparison of Amitriptyline and Cyproheptadine: A Randomized Clinical Trial.
Trial report in The American journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- European Guideline on Chronic Nausea and Vomiting-A UEG and ESNM Consensus for Clinical Management.United European gastroenterology journal · 2025Guideline
- Cyclic Vomiting Syndrome in Children.Frontiers in neurology · 2020Pooled it
- Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association.Neurogastroenterology and motility · 2019Guideline
- Disease characteristics and long-term outcomes of cyclic vomiting syndrome in Singaporean children.World journal of gastrointestinal pharmacology and therapeutics · 2025Article
- Cyclic vomiting syndrome: Future clinical and research priorities for: Special supplement/proceedings of 3rd international symposium.Neurogastroenterology and motility · 2025Review
- Evidence-based review and frontiers of migraine therapy.Neurogastroenterology and motility · 2025Review
- Prophylactic Cyproheptadine to Control Paroxysmal Hemicrania Attacks: A Preliminary Investigation.Advanced biomedical research · 2024Article
- Early diagnosis of neonatal-onset cyclic vomiting syndrome.Nagoya journal of medical science · 2023Article
- Cyclic Vomiting Syndrome in Pediatric Patients: A Review of Therapeutics.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Migraine and Its Equivalents: What Do They Share? A Narrative Review on Common Pathophysiological Patterns.Life (Basel, Switzerland) · 2021Review
- Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review.Frontiers in pediatrics · 2021Article
- Management of cyclic vomiting syndrome in adults: Evidence review.Neurogastroenterology and motility · 2019Review
- Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions.Neurogastroenterology and motility · 2019Review
- Comparison of the Efficacy of Amitriptyline and Topiramate in Prophylaxis of Cyclic Vomiting Syndrome.Iranian journal of child neurology · 2019Article
- Managing cyclic vomiting syndrome in children: beyond the guidelines.European journal of pediatrics · 2018Review
- Cyclic Vomiting Syndrome in Children.Current pain and headache reports · 2018Review
- Cyclic vomiting syndrome: diagnostic approach and current management strategies.Clinical and experimental gastroenterology · 2018Review
- Cyclic Vomiting Syndrome: Randomized Controlled Trials Are also Needed in Adults.The American journal of gastroenterology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCyclic vomiting syndrome (CVS) is a common functional gastrointestinal disorder characterized by recurrent episodes of nausea and vomiting. There is no definite treatment for the condition, although some medications are recommended. We aimed to compare the efficacy of amitriptyline and cyproheptadine in prophylactic therapy of CVS.
methodsThis is a single-blinded randomized clinical trial conducted during 2015-2016 in Isfahan, Iran. Sixty-four children who were 3-15 years old, with a diagnosis of CVS (based on Rome III criteria), were included in the study and were randomly divided into two groups of amitriptyline and cyproheptadine. They were followed for 6 months, looking for frequency and duration of attacks as the primary outcome.
resultsThe mean monthly frequency of attacks in the last 2 months of the study in the amitriptyline and cyproheptadine group were 0.38±0.55 and 0.59±0.71, respectively (P-value=0.197), after intervention. The mean duration of attacks between amitriptyline and cyproheptadine group were 1.41±2.86 and 1.81±2.22 h, respectively (P-value=0.212). In the amitriptyline group 65.6% of patients reported 100% remission, whereas in the cyproheptadine group 50% reported full remission (P-value=0.206).
conclusionsThere was no superiority of one of the medications over the other. We did not find any age-related effect on the efficacy of these medications as well.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.