ArticleNature communications2017
Physical limits to biomechanical sensing in disordered fibre networks.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
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- Physical extraction of antigen and information.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Optomechanically Actuated Hydrogel Platform for Cell Stimulation with Spatial and Temporal Resolution.ACS biomaterials science & engineering · 2023Article
- Local response and emerging nonlinear elastic length scale in biopolymer matrices.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Immune cells use active tugging forces to distinguish affinity and accelerate evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Reciprocity of Cell Mechanics with Extracellular Stimuli: Emerging Opportunities for Translational Medicine.Small (Weinheim an der Bergstrasse, Germany) · 2022Review
- Risky interpretations across the length scales: continuum vs. discrete models for soft tissue mechanobiology.Biomechanics and modeling in mechanobiology · 2022Article
- Effect of matrix heterogeneity on cell mechanosensing.Soft matter · 2021Article
- 3D magnetically controlled spatiotemporal probing and actuation of collagen networks from a single cell perspective.Lab on a chip · 2021Article
- The mechanics of fibrillar collagen extracellular matrix.Cell reports. Physical science · 2021Article
- The mechanics and dynamics of cancer cells sensing noisy 3D contact guidance.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Active biomaterials for mechanobiology.Biomaterials · 2021Review
- Predictive assembling model reveals the self-adaptive elastic properties of lamellipodial actin networks for cell migration.Communications biology · 2020Article
- Physical limits to sensing material properties.Nature communications · 2020Article
- Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics.iScience · 2020Article
- Regulation and dynamics of force transmission at individual cell-matrix adhesion bonds.Science advances · 2020Article
- Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Heterogeneity and nonaffinity of cell-induced matrix displacements.Physical review. E · 2018Article
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6 authors.
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Abstract
Cells actively probe and respond to the stiffness of their surroundings. Since mechanosensory cells in connective tissue are surrounded by a disordered network of biopolymers, their in vivo mechanical environment can be extremely heterogeneous. Here we investigate how this heterogeneity impacts mechanosensing by modelling the cell as an idealized local stiffness sensor inside a disordered fibre network. For all types of networks we study, including experimentally-imaged collagen and fibrin architectures, we find that measurements applied at different points yield a strikingly broad range of local stiffnesses, spanning roughly two decades. We verify via simulations and scaling arguments that this broad range of local stiffnesses is a generic property of disordered fibre networks. Finally, we show that to obtain optimal, reliable estimates of global tissue stiffness, a cell must adjust its size, shape, and position to integrate multiple stiffness measurements over extended regions of space.
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