Evidence map›Paper›PMID 28719572›Full record

Trial reportMedical science monitor : international medical journal of experimental and clinical research2017

Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia Therapy.

Rodolphe Nenert, Jane B Allendorfer, Amber M Martin, Christi Banks, Angel Ball, Jennifer Vannest, Aimee R Dietz, Jerzy P Szaflarski

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Article
  7. Review
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  14. Article
  15. Is Aphasia Treatment Beneficial for the Elderly? A Review of Recent Evidence.Current physical medicine and rehabilitation reports · 2020
    Article
  16. Review
  17. Constrained-Induced Dysarthria Therapy: Case Report.Annals of rehabilitation medicine · 2019
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Rodolphe NenertDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jane B AllendorferDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Amber M MartinDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Christi BanksDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Angel Ball
Jennifer VannestDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Aimee R Dietz
Jerzy P SzaflarskiDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USCincinnati Children's Hospital Medical Center · USTexas A&M University – Kingsville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Recovery from post-stroke aphasia is a long and complex process with an uncertain outcome. Various interventions have been proposed to augment the recovery, including constraint-induced aphasia therapy (CIAT). CIAT has been applied to patients suffering from post-stroke aphasia in several unblinded studies to show mild-to-moderate linguistic gains. The aim of the present study was to evaluate the neuroimaging correlates of CIAT in patients with chronic aphasia related to left middle cerebral artery stroke. MATERIAL AND METHODS Out of 24 patients recruited in a pilot randomized blinded trial of CIAT, 19 patients received fMRI of language. Eleven of them received CIAT (trained) and eight served as a control group (untrained). Each patient participated in three fMRI sessions (before training, after training, and 3 months later) that included semantic decision and verb generation fMRI tasks, and a battery of language tests. Matching healthy control participants were also included (N=38; matching based on age, handedness, and sex). RESULTS Language testing showed significantly improved performance on Boston Naming Test (BNT; p<0.001) in both stroke groups over time and fMRI showed differences in the distribution of the areas involved in language production between groups that were not present at baseline. Further, regression analysis with BNT indicated changes in brain regions correlated with behavioral performance (temporal gyrus, postcentral gyrus, precentral gyrus, thalamus, left middle and superior frontal gyri). CONCLUSIONS Overall, our results suggest the possibility of language-related cortical plasticity following stroke-induced aphasia with no specific effect from CIAT training.

Indexed as

AgedAphasiaBrainCerebral ArteriesFemaleFrontal LobeHumansLanguageLanguage TestsLanguage TherapyMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingNeuropsychological TestsPilot Projects

Identifiers

PMID28719572
PMCPMC5529460
OpenAlexW2737486401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.