Evidence map›Paper›PMID 28719495›Full record

ArticleThe Pediatric infectious disease journal2017

Late-Onset Hiv Encephalopathy In Children With Long-Standing Virologic Suppression Followed By Slow Spontaneous Recovery Despite no Change In Antiretroviral Therapy: 4 Case Reports.

Steve Innes, Ronald van Toorn, Kennedy Otwombe, Els Dobbels, Gert van Zyl, Mark F Cotton, Barbara Laughton

Abstract readCase Reports
In one paragraph

Article in The Pediatric infectious disease journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Neurocognitive Complications of Pediatric HIV Infections.Current topics in behavioral neurosciences · 2021
    Article
  2. Propelling the Pediatric HIV Therapeutic Agenda With Science, Innovation, and Collaboration.Journal of acquired immune deficiency syndromes (1999) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Steve InnesFrom the *Children's Infectious Diseases Clinical Research Unit (KID-CRU), Stellenbosch University, and †Department of Paediatrics and Child Health, Tygerberg Children's Hospital, Cape Town, South Africa; ‡Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Soweto, South Africa; and §Division of Medical Virology, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.
Ronald van Toorn
Kennedy Otwombe
Els Dobbels
Gert van Zyl
Mark F Cotton
Barbara Laughton
Stellenbosch University · ZA

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
The effect of ART on rates and transmission of TBU19AI053217 · NIAID · WITS HEALTH CONSORTIUM (PTY), LTD · PI VIOLARI, AVY · 2002 to 2011
$44.9M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Stellenbosch University Clinical Trial Unit, Cape Town, South AfricaUM1AI069521 · NIAID · STELLENBOSCH UNIVERSITY · PI Shaun Barnabas, Anneke Catharina Hesseling · 2012 to 2026
$21.5M
Stellenbosch University Clinical Trial Unit, Cape Town, South AfricaU01AI069521 · NIAID · STELLENBOSCH UNIVERSITY · PI COTTON, MARK FREDRIC · 2007 to 2011
$8.4M
Latent reservoir characterization and correlations with neurocognitive functioninR01MH105134 · NIMH · STELLENBOSCH UNIVERSITY · PI COTTON, MARK FREDRIC · 2014 to 2018
$3.1M
Screening for atherosclerotic vascular disease in HIV-infected childrenR01HD083042 · NICHD · STELLENBOSCH UNIVERSITY · PI HAUBRICH, RICHARD H, INNES, STEVE · 2015 to 2019
$1.6M
FIC NIH HHS R24 TW007988NIAID NIH HHS P30 AI036214NIAID NIH HHS U01 AI069521NIAID NIH HHS U19 AI053217NIAID NIH HHS UM1 AI069521NIMH NIH HHS R01 MH105134Wellcome Trust
6 · The paper itself

Abstract

We describe 4 Children with HIV Early Antiretroviral Therapy trial participants with late-onset HIV encephalopathy despite long-standing viral suppression in blood and undetectable HIV DNA and RNA polymerase chain reaction in cerebrospinal fluid. Extensive investigations revealed no alternative etiology. Reassuringly, all 4 experienced slow spontaneous recovery despite no change in antiretroviral therapy. Virally suppressed HIV-infected children remain at risk for fluctuating neurologic signs and symptoms.

Indexed as

AIDS Dementia ComplexAnti-Retroviral AgentsChildChild, PreschoolFemaleHIV-1HIV InfectionsHumansInfantMaleRemission, SpontaneousRNA, ViralSouth AfricaViral LoadAnti-Retroviral AgentsRNA, Viral

Identifiers

PMID28719495
PMCPMC5638699
OpenAlexW2737788189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.