ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)
Fourteen Day In Vivo Testing of a Compliant Thoracic Artificial Lung.
Article in ASAIO journal (American Society for Artificial Internal Organs : 1992). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 36 citations in OpenAlex.
- Five-day Wearable Respiratory Support With a Novel Ambulatory Pulmonary Assist System in an Awake Ovine Model.Transplantation · 2025Article
- Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations.BMC anesthesiology · 2025Article
- Hemocompatibility Evaluation of a Novel Ambulatory Pulmonary Assist System Using a Lightweight Axial-Flow Pump.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2024Article
- Effect of artificial lung fiber bundle geometric design on micro- and macro-scale clot formation.Bioengineering & translational medicine · 2024Article
- Ambulatory 7-day mechanical circulatory support in sheep model of pulmonary hypertension and right heart failure.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- Oxygenation performance assessment of an artificial lung in different central anatomic configurations.The International journal of artificial organs · 2023Article
- First in vivo assessment of RAS-Q technology as lung support device for pulmonary hypertension.The International journal of artificial organs · 2021Article
- A Model of Pediatric End-Stage Lung Failure in Small Lambs <20 kg.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- 72-Hour in vivo evaluation of nitric oxide generating artificial lung gas exchange fibers in sheep.Acta biomaterialia · 2019Article
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9 authors at 2 institutions in 1 country.
Funding
Abstract
The compliant thoracic artificial lung (cTAL) has been studied in acute in vivo and in vitro experiments. The cTAL's long-term function and potential use as a bridge to lung transplantation are assessed presently. The cTAL without anticoagulant coatings was attached to sheep (n = 5) via the pulmonary artery and left atrium for 14 days. Systemic heparin anticoagulation was used. Compliant thoracic artificial lung resistance, cTAL gas exchange, hematologic parameters, and organ function were recorded. Two sheep were euthanized for nondevice-related issues. The cTAL's resistance averaged 1.04 ± 0.05 mmHg/(L/min) with no statistically significant increases. The cTAL transferred 180 ± 8 ml/min of oxygen with 3.18 ± 0.05 L/min of blood flow. Except for transient surgical effects, organ function markers were largely unchanged. Necropsies revealed pulmonary edema and atelectasis but no other derangements. Hemoglobin levels dropped with device attachment but remained steady at 9.0 ± 0.1 g/dl thereafter. In a 14 day experiment, the cTAL without anticoagulant coatings exhibited minimal clot formation. Sheep physiology was largely unchanged except for device attachment-related hemodilution. This suggests that patients treated with the cTAL should not require multiple blood transfusions. Once tested with anticoagulant coatings and plasma resistant gas exchange fiber, the cTAL could serve as a bridge to transplantation.
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