Evidence map›Paper›PMID 28719287›Full record

Trial reportThe American journal of tropical medicine and hygiene2017

Phase 1 Randomized Study of a Tetravalent Dengue Purified Inactivated Vaccine in Healthy Adults in the United States.

Alexander C Schmidt, Leyi Lin, Luis J Martinez, Richard C Ruck, Kenneth H Eckels, Alix Collard, Rafael De La Barrera, Kristopher M Paolino, Jean-François Toussaint, Edith Lepine and 3 more

Abstract readClinical Trial, Phase IRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Safety and Immunogenicity of an AS03The American journal of tropical medicine and hygiene · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexander C SchmidtGSK Vaccines, Rixensart, Belgium.
Leyi LinWalter Reed Army Institute of Research, Silver Spring, Maryland.
Luis J MartinezWalter Reed Army Institute of Research, Silver Spring, Maryland.
Richard C RuckWalter Reed Army Institute of Research, Silver Spring, Maryland.
Kenneth H EckelsWalter Reed Army Institute of Research, Silver Spring, Maryland.
Alix CollardGSK Vaccines, Rixensart, Belgium.
Rafael De La BarreraWalter Reed Army Institute of Research, Silver Spring, Maryland.
Kristopher M PaolinoWalter Reed Army Institute of Research, Silver Spring, Maryland.
Jean-François ToussaintGSK Vaccines, Rixensart, Belgium.
Edith LepineGSK Vaccines, King of Prussia, Pennsylvania.
Bruce L InnisGSK Vaccines, King of Prussia, Pennsylvania.
Richard G JarmanWalter Reed Army Institute of Research, Silver Spring, Maryland.
Stephen J ThomasWalter Reed Army Institute of Research, Silver Spring, Maryland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AbstractThe safety and immunogenicity of four formulations of an investigational tetravalent dengue purified inactivated vaccine (DPIV), formulated at 1 or 4 μg with aluminum hydroxide (alum) or at 1 μg with an adjuvant system (AS01

Indexed as

Adjuvants, ImmunologicAdolescentAdultAlum CompoundsAntibodies, ViralDengueDengue VaccinesDengue VirusDose-Response Relationship, DrugFemaleHumansMaleSingle-Blind MethodUnited StatesVaccinationVaccines, InactivatedAdjuvants, ImmunologicAlum Compoundsaluminum sulfateAntibodies, ViralDengue VaccinesVaccines, Inactivated

Identifiers

PMID28719287
PMCPMC5462566

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.