ArticleThe American journal of tropical medicine and hygiene2017
High Hepatitis E Seroprevalence Among Displaced Persons in South Sudan.
Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Assessment of Population Immunity to Enteric Hepatitis Viruses in the Population of Belgrade.Epidemiologia (Basel, Switzerland) · 2026Article
- Current global estimates, risk factors, and knowledge gaps for Hepatitis E virus (HEV): A scoping review.PLoS neglected tropical diseases · 2026Article
- Unveiling hepatitis E virus diversity in Sudan's internally displaced populations: a molecular epidemiology approach.Tropical medicine and health · 2025Article
- High confidence and demand for hepatitis E vaccine during an outbreak in Bentiu, South Sudan: A qualitative study.PLOS global public health · 2025Article
- Seroprevalence patterns of viral hepatitis B, C, and E among internally displaced persons in Borno State, Nigeria.IJID regions · 2024Article
- Seroincidence of Enteric Fever, Juba, South Sudan.Emerging infectious diseases · 2022Article
- The COVID-19 pandemic in the African continent.BMC medicine · 2022Article
- Epidemiological characterization of COVID-19 in displaced populations of South Sudan.The Pan African medical journal · 2022Article
- Setting a Course for Preventing Hepatitis E in Low and Lower-Middle-Income Countries: A Systematic Review of Burden and Risk Factors.Open forum infectious diseases · 2021Article
- Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health.Pathogens (Basel, Switzerland) · 2020Review
- Hepatitis E should be considered a neglected tropical disease.PLoS neglected tropical diseases · 2019Article
- Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso.Viruses · 2019Article
- Analysis of IgG Anti-HEV Antibody Protective Levels During Hepatitis E Virus Reinfection in Experimentally Infected Rhesus Macaques.The Journal of infectious diseases · 2019Article
- Case Report: Acute Hepatitis E in a Pediatric Traveler Presenting with Features of Autoimmune Hepatitis: A Diagnostic and Therapeutic Challenge.The American journal of tropical medicine and hygiene · 2019Review
- Outbreak of Hepatitis E Virus Infection in Displaced Persons Camps in Diffa Region, Niger, 2017.The American journal of tropical medicine and hygiene · 2018Article
- Seroprevalence and risk factors of recent infection with hepatitis E virus during an acute outbreak in an urban setting in Chad, 2017.BMC infectious diseases · 2018Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 5 countries.
Funding
Abstract
AbstractLarge protracted outbreaks of hepatitis E virus (HEV) have been documented in displaced populations in Africa over the past decade though data are limited outside these exceptional settings. Serological studies can provide insights useful for improving surveillance and disease control. We conducted an age-stratified serological survey using samples previously collected for another research study from 206 residents of an internally displaced person camp in Juba, South Sudan. We tested serum for anti-HEV antibodies (IgM and IgG) and estimated the prevalence of recent and historical exposure to the virus. Using data on individuals' serostatus, camp arrival date, and state of origin, we used catalytic transmission models to estimate the relative risk of HEV infection in the camp compared with that in the participants' home states. The age-adjusted seroprevalence of anti-HEV IgG was 71% (95% confidence interval = 63-78), and 4% had evidence of recent exposure (IgM). We estimated HEV exposure rates to be more than 2-fold (hazard ratio = 2.3, 95% credible interval = 0.3-5.8) higher in the camp than in the participants' home states, although this difference was not statistically significant. HEV transmission may be higher than previously appreciated, even in the absence of reported cases. Improved surveillance in similar settings is needed to understand the burden of disease and minimize epidemic impact through early detection and response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.