Evidence map›Paper›PMID 28719257›Full record

ArticleThe American journal of tropical medicine and hygiene2017

No Serologic Evidence of Middle East Respiratory Syndrome Coronavirus Infection Among Camel Farmers Exposed to Highly Seropositive Camel Herds: A Household Linked Study, Kenya, 2013.

Peninah Munyua, Victor Max Corman, Austine Bitek, Eric Osoro, Benjamin Meyer, Marcel A Müller, Erik Lattwein, S M Thumbi, Rees Murithi, Marc-Alain Widdowson and 2 more

Open access · greenAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
8.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Peninah MunyuaGlobal Disease Detection Program, Division of Global Health Protection, U.S. Centers for Disease Control and Prevention, Nairobi, Kenya.
Victor Max CormanInstitute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Austine BitekState Department of Veterinary Services; Ministry of Agriculture Livestock and Fisheries, Nairobi, Kenya.
Eric OsoroDepartment of Preventive and Promotive Health, Ministry of Health, Nairobi, Kenya.
Benjamin MeyerInstitute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Marcel A MüllerInstitute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Erik LattweinEUROIMMUN AG, Lübeck, Germany.
S M ThumbiPaul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington.
Rees MurithiState Department of Veterinary Services; Ministry of Agriculture Livestock and Fisheries, Nairobi, Kenya.
Marc-Alain WiddowsonGlobal Disease Detection Program, Division of Global Health Protection, U.S. Centers for Disease Control and Prevention, Nairobi, Kenya.
Christian DrostenGerman Centre for Infection Research, Partner Site Bonn-Cologne, Bonn, Germany.
M Kariuki NjengaPaul G. Allen School for Global Animal Health, Washington State University, Pullman, Washington.
University of Bonn · DECenters for Disease Control and Prevention · KEMinistry of Agriculture Livestock and Fisheries · KEEuroimmun Medizinische Labordiagnostika (Germany) · DEGerman Center for Infection Research · DEKenya Medical Research Institute · KEMinistry of Health · KEWashington State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AbstractHigh seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) among camels has been reported in Kenya and other countries in Africa. To date, the only report of MERS-CoV seropositivity among humans in Kenya is of two livestock keepers with no known contact with camels. We assessed whether persons exposed to seropositive camels at household level had serological evidence of infection. In 2013, 760 human and 879 camel sera were collected from 275 and 85 households respectively in Marsabit County. Data on human and animal demographics and type of contact with camels were collected. Human and camel sera were tested for anti-MERS-CoV IgG using a commercial enzyme-linked immunosorbent assay (ELISA) test. Human samples were confirmed by plaque reduction neutralization test (PRNT). Logistic regression was used to identify factors associated with seropositivity. The median age of persons sampled was 30 years (range: 5-90) and 50% were males. A quarter (197/760) of the participants reported having had contact with camels defined as milking, feeding, watering, slaughtering, or herding. Of the human sera, 18 (2.4%) were positive on ELISA but negative by PRNT. Of the camel sera, 791 (90%) were positive on ELISA. On univariate analysis, higher prevalence was observed in female and older camels over 4 years of age (

Indexed as

AdolescentAdultAgedAged, 80 and overAnimalsAntibodies, ViralCamelusChildChild, PreschoolCoronavirus InfectionsCross-Sectional StudiesDisease ReservoirsFarmersFemaleHumansImmunoglobulin GAntibodies, ViralImmunoglobulin G

Identifiers

PMID28719257
PMCPMC5462565
OpenAlexW2599148924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.