Evidence map›Paper›PMID 28719255›Full record

ArticleThe American journal of tropical medicine and hygiene2017

Patient-Reported Adverse Effects Associated with Combination Antiretroviral Therapy and Coadministered Enzyme-Inducing Antiepileptic Drugs.

Melissa A Elafros, Gretchen L Birbeck, Joseph C Gardiner, Omar K Siddiqi, Izukanji Sikazwe, Nigel Paneth, Christopher M Bositis, Jason F Okulicz

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Hearing-Functioning Problems Across High-Burden Adult Health Conditions in Africa.International journal of environmental research and public health · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Melissa A ElafrosDepartment of Internal Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland.
Gretchen L BirbeckEpilepsy Care Team, Chikankata Hospital, Mazabuka, Zambia.
Joseph C GardinerDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan.
Omar K SiddiqiDepartment of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
Izukanji SikazweCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Nigel PanethDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan.
Christopher M BositisGreater Lawrence Family Health Center, Lawrence, Massachusetts.
Jason F OkuliczInfectious Disease Service, San Antonio Military Medical Center, San Antonio, Texas.
Michigan State University · USCentre for Infectious Disease Research in Zambia · ZMGreater Lawrence Family Health Center · USJohns Hopkins Bayview Medical Center · USSan Antonio Military Medical Center · USUniversity of Rochester · USUniversity of Zambia · ZM

Funding

Cohort of HIV-Associated Seizures and Epilepsy in Zambia (CHASE): Scale up and expansion informed by R21 FindingsR01NS094037 · NINDS · UNIVERSITY OF ROCHESTER · PI BIRBECK, GRETCHEN L., SIKAZWE, IZUKANJI · 2015 to 2019
$3.0M
Epilepsy-associated stigma in Zambia: Evidence-based interventions and outcomesR01NS061693 · NINDS · MICHIGAN STATE UNIVERSITY · PI BIRBECK, GRETCHEN L. · 2008 to 2012
$1.4M
A Cohort Study of Seizures and Epilepsy in HIV+ Zambian AdultsR21NS073509 · NINDS · MICHIGAN STATE UNIVERSITY · PI BIRBECK, GRETCHEN L. · 2011 to 2012
$245k
NINDS NIH HHS R01 NS061693NINDS NIH HHS R01 NS094037NINDS NIH HHS R21 NS073509
6 · The paper itself

Abstract

AbstractConcurrent treatment with combination antiretroviral therapy (cART) and an enzyme-inducing antiepileptic drug (EI-AED) is common in resource-limited settings; however, the incidence and impact of adverse effects in cotreated patients is largely unknown. Symptoms of adverse effects were assessed by both spontaneous report and checklist for 145 human immunodeficiency virus (HIV)-infected Zambian adults initiating various treatment combinations, such as cART with an EI-AED (

Indexed as

AdultAnticonvulsantsAnti-HIV AgentsDrug Therapy, CombinationFemaleFollow-Up StudiesHIV InfectionsHumansMaleMedication AdherenceMiddle AgedNauseaViral LoadVomitingZambiaAnticonvulsantsAnti-HIV Agents

Identifiers

PMID28719255
PMCPMC5462593
OpenAlexW2607088026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.