ArticleActa physiologica (Oxford, England)2018
Serotonergic paraneurones in the female mouse urethral epithelium and their potential role in peripheral sensory information processing.
Article in Acta physiologica (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 35 citations in OpenAlex.
- Development of urinary impairment after spinal cord injury courses with altered urethral serotonin signalling in the female mice.Scientific reports · 2025Article
- Advancing our Understanding of the Urothelium and Lamina Propria, Hormone Receptors, Vascular Supply, and Sensory Aspects of the Female Human Urethra.Neurourology and urodynamics · 2025Review
- Identification and Validation of Oxidative Stress-Related Diagnostic Marker Genes and Immune Landscape in Ulcerative Interstitial Cystitis by Integrating Bioinformatics and Machine Learning.Journal of inflammation research · 2025Article
- Spinal Cord Injury Causes Marked Tissue Rearrangement in the Urethra-Experimental Study in the Rat.International journal of molecular sciences · 2022Article
- Activation of uroepithelial 5-HTFrontiers in physiology · 2022Article
- Age is associated with reduced urethral pressure and afferent activity in rat.Physiological reports · 2021Article
- Neurophysiological control of urinary bladder storage and voiding-functional changes through development and pathology.Pediatric nephrology (Berlin, Germany) · 2021Review
- Spinal cord stimulation ameliorates detrusor over-activity and visceromotor pain responses in rats with cystitis.Neurourology and urodynamics · 2019Article
- Feline Interstitial Cystitis Enhances Mucosa-Dependent Contractile Responses to Serotonin.International neurourology journal · 2018Article
- Role of neurogenic inflammation in local communication in the visceral mucosa.Seminars in immunopathology · 2018Review
- Inflammation and Tissue Remodeling in the Bladder and Urethra in Feline Interstitial Cystitis.Frontiers in systems neuroscience · 2018Article
- Distribution of Neuroendocrine Cells and Hormone Receptors in the Male Proximal Urethra: Implications for Sensory Function and the Impact of Aging.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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10 authors at 2 institutions in 1 country.
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Abstract
aimThe mechanisms underlying detection and transmission of sensory signals arising from visceral organs, such as the urethra, are poorly understood. Recently, specialized ACh-expressing cells embedded in the urethral epithelium have been proposed as chemosensory sentinels for detection of bacterial infection. Here, we examined the morphology and potential role in sensory signalling of a different class of specialized cells that express serotonin (5-HT), termed paraneurones.
methodsUrethrae, dorsal root ganglia neurones and spinal cords were isolated from adult female mice and used for immunohistochemistry and calcium imaging. Visceromotor reflexes (VMRs) were recorded in vivo.
resultsWe identified two morphologically distinct groups of 5-HT
conclusionThese morphological and functional findings provide insights into a putative paraneurone-neural network within the urethra that utilizes 5-HT signalling, presumably from paraneurones, to modulate primary sensory pathways carrying nociceptive and non-nociceptive (mechano-sensitive) information to the central nervous system.
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