Evidence map›Paper›PMID 28718923›Full record

ArticleProteins2017

Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.

Andrea Bazzoli, David J Vance, Michael J Rudolph, Yinghui Rong, Siva Krishna Angalakurthi, Ronald T Toth, C Russell Middaugh, David B Volkin, David D Weis, John Karanicolas and 1 more

Abstract read
In one paragraph

Article in Proteins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. A Rapid and Modular Nanobody Assay for Plug-and-Play Antigen Detection.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrea BazzoliCenter for Computational Biology, University of Kansas, Lawrence, Kansas, 66045.
David J VanceNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, New York, 12208.ORCID http://orcid.org/0000-0002-9913-7722
Michael J RudolphNew York Structural Biology Center, New York, New York, 10027.
Yinghui RongNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, New York, 12208.
Siva Krishna AngalakurthiDepartment of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas, 66045.
Ronald T TothDepartment of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas, 66045.
C Russell MiddaughDepartment of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas, 66045.
David B VolkinDepartment of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas, 66045.
David D WeisDepartment of Chemistry, University of Kansas, Lawrence, Kansas, 66045.ORCID http://orcid.org/0000-0003-3032-1211
John KaranicolasCenter for Computational Biology, University of Kansas, Lawrence, Kansas, 66045.
Nicholas J MantisNew York State Department of Health, Division of Infectious Diseases, Wadsworth Center, Albany, New York, 12208.ORCID http://orcid.org/0000-0002-5083-8640

Funding

NIAID NIH HHS HHSN272201400021C
6 · The paper itself

Abstract

In this report we investigated, within a group of closely related single domain camelid antibodies (V

Indexed as

Antibodies, NeutralizingModels, MolecularRicinSingle-Domain AntibodiesAmino Acid SequenceAnimalsCamelidaeEpitope MappingProtein BindingProtein EngineeringSequence AlignmentAntibodies, NeutralizingRicinSingle-Domain Antibodiesantibody engineeringepitope mappingstructure-based protein modelingvaccine

Identifiers

PMID28718923
PMCPMC5754017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.