A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

1. Direct cellular contact byScience advances · 2026
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2. Light-induced analgesia provides a drug-free optical method for pain relief via activation of TRAAK kNature communications · 2026
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3. A Deep Learning Methodology for Screening New Natural Therapeutic Candidates for Pharmacological Cardioversion and Anticoagulation in the Treatment and Management of Atrial Fibrillation.Biomedicines · 2025
   Article
4. Exploring Mycolactone-The Unique Causative Toxin of Buruli Ulcer: Biosynthetic, Synthetic Pathways, Biomarker for Diagnosis, and Therapeutic Potential.Toxins · 2024
   Review
5. Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer.PLoS pathogens · 2023
   Article
6. Mycolactone A vs. B: Multiscale Simulations Reveal the Roles of Localization and Association in Isomer-Specific Toxicity.Toxins · 2023
   Article
7. Mycolactone A vs. B: Does localization or association explain isomer-specific toxicity?bioRxiv : the preprint server for biology · 2023
   Article
8. Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure.International journal of molecular sciences · 2023
   Article
9. Behavioral interplay between mosquito and mycolactone produced by Mycobacterium ulcerans and bacterial gene expression induced by mosquito proximity.PloS one · 2023
   Article
10. Can membrane composition traffic toxins? Mycolactone and preferential membrane interactions.Biophysical journal · 2022
    Article
11. The Angiotensin ATPharmacological reviews · 2022
    Review
12. Making Sense of Quorum Sensing at the Intestinal Mucosal Interface.Cells · 2022
    Review
13. Protective Efficacy of BCG Vaccine againstVaccines · 2022
    Review
14. The Angiotensin II Type 2 Receptor, a Target for Protection and Regeneration of the Peripheral Nervous System?Pharmaceuticals (Basel, Switzerland) · 2021
    Review
15. Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology.PLoS pathogens · 2020
    Article
16. Pharmacologic management ofExpert review of clinical pharmacology · 2020
    Review
17. Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls.Toxins · 2019
    Review
18. Neuronal Regulation of Immunity in the Skin and Lungs.Trends in neurosciences · 2019
    Review
19. Mycolactone Toxin Membrane Permeation: Atomistic versus Coarse-Grained MARTINI Simulations.Biophysical journal · 2019
    Article
20. Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters.Frontiers in pharmacology · 2019
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

17 authors at 4 institutions in 2 countries.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as