Evidence map›Paper›PMID 28718687›Full record

ArticleChannels (Austin, Tex.)2017

Do sodium channel proteolytic fragments regulate sodium channel expression?

Donatus O Onwuli, Laia Yañez-Bisbe, Mel Lina Pinsach-Abuin, Anna Tarradas, Ramon Brugada, John Greenman, Sara Pagans, Pedro Beltran-Alvarez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Channels (Austin, Tex.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Donatus O Onwulia Biomedical Sciences , School of Life Sciences, University of Hull , Kingston upon Hull , UK.
Laia Yañez-Bisbeb Cardiovascular Genetics Center , Institut d'Investigació Biomèdica de Girona (IDIBGI), University of Girona , Girona , Spain.
Mel Lina Pinsach-Abuinb Cardiovascular Genetics Center , Institut d'Investigació Biomèdica de Girona (IDIBGI), University of Girona , Girona , Spain.
Anna Tarradasb Cardiovascular Genetics Center , Institut d'Investigació Biomèdica de Girona (IDIBGI), University of Girona , Girona , Spain.
Ramon Brugadab Cardiovascular Genetics Center , Institut d'Investigació Biomèdica de Girona (IDIBGI), University of Girona , Girona , Spain.
John Greenmana Biomedical Sciences , School of Life Sciences, University of Hull , Kingston upon Hull , UK.
Sara Pagansb Cardiovascular Genetics Center , Institut d'Investigació Biomèdica de Girona (IDIBGI), University of Girona , Girona , Spain.ORCID http://orcid.org/0000-0003-0772-6982
Pedro Beltran-Alvareza Biomedical Sciences , School of Life Sciences, University of Hull , Kingston upon Hull , UK.ORCID http://orcid.org/0000-0001-8136-8963
Universitat de Girona · ESUniversity of Hull · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cardiac voltage-gated sodium channel (gene: SCN5A, protein: Na

Indexed as

Action PotentialsCell LineGene ExpressionGene Expression RegulationHumansIon Channel GatingMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelPromoter Regions, GeneticProtein SubunitsProteolysisNAV1.5 Voltage-Gated Sodium ChannelProtein Subunitsgene expressionmutagenesisnuclear localization signaltranscription factorvoltage-gated sodium channel

Identifiers

PMID28718687
PMCPMC5626351
OpenAlexW2737400893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.