Evidence map›Paper›PMID 28718670›Full record

ArticleNutrition and cancer

Dietary Inflammatory Index and Renal Cell Carcinoma Risk in an Italian Case-Control Study.

Nitin Shivappa, James R Hébert, Valentina Rosato, Marta Rossi, Maurizio Montella, Diego Serraino, Carlo La Vecchia

Open access · greenAbstract read
In one paragraph

Article in Nutrition and cancer. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  9. Phytochemicals in Gynecological Cancer Prevention.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Nitin Shivappaa Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA.
James R Héberta Cancer Prevention and Control Program, University of South Carolina , Columbia , South Carolina , USA.
Valentina Rosatoe Department of Clinical Sciences and Community Health , Università degli Studi di Milano , Milan , Italy.
Marta Rossie Department of Clinical Sciences and Community Health , Università degli Studi di Milano , Milan , Italy.
Maurizio Montellag Unit of Epidemiology , 'Fondazione G. Pascale', Istituto Nazionale dei Tumori , Naples , Italy.
Diego Serrainoh Unit of Cancer Epidemiology , CRO Aviano National Cancer Institute , Aviano (PN) , Italy.
Carlo La Vecchiae Department of Clinical Sciences and Community Health , Università degli Studi di Milano , Milan , Italy.
University of Milan · ITUniversity of South Carolina · USCentro di Riferimento Oncologico · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · IT

Funding

Developing the Dietary Inflammatory Index for Clinical ApplicationR44DK103377 · NIDDK · CONNECTING HEALTH INNOVATIONS, LLC · PI SHIVAPPA, NITIN, WIRTH, MICHAEL DAVID · 2014 to 2016
$1.8M
NIDDK NIH HHS R44 DK103377
6 · The paper itself

Abstract

backgroundThe relation between diet-related inflammation and renal cell carcinoma (RCC) has not been investigated.

methodsIn this study, we explored the association between the dietary inflammatory index (DII) and RCC in an Italian case-control study conducted between 1992 and 2004. Cases were 767 patients with incident, histologically confirmed RCC. Controls were 1534 subjects admitted to the same hospitals as cases for various acute, nonneoplastic conditions. The DII was computed based on dietary intake assessed using a reproducible and valid 78-item food frequency questionnaire. Odds ratios (ORs) were estimated through logistic regression models conditioned on age, sex, and center, and adjusted for recognized confounding factors, including total energy intake.

resultsSubjects in the highest quartile of DII scores (i.e., with the most proinflammatory diets) had a higher risk of RCC compared to subjects in the lowest quartile [OR 1.41, 95% confidence interval (CI) 1.02, 1.97; p-trend = 0.04)]. Apparently stronger associations were observed among females (OR 1.68, 95% CI 0.93, 3.03), subjects aged <60 yr (OR 1.77, 95% CI 1.05, 2.98), body mass index ≥25 kg/m

conclusionA proinflammatory diet is associated with increased RCC risk.

Indexed as

AdultAgedBody Mass IndexCarcinoma, Renal CellCase-Control StudiesDietDietary SugarsFemaleFruitHumansInflammationItalyLogistic ModelsMaleMeatMiddle AgedDietary Sugars

Identifiers

PMID28718670
PMCPMC6089838
OpenAlexW2738842897

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.